Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD023839-08
Application #
2198968
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1988-02-03
Project End
1998-01-11
Budget Start
1996-04-01
Budget End
1998-01-11
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Guo, Jing; Shi, Lanying; Gong, Xuhong et al. (2016) Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes. J Cell Sci 129:3091-103
Wigglesworth, Karen; Lee, Kyung-Bon; Emori, Chihiro et al. (2015) Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles. Biol Reprod 92:23
Peng, Jia; Wigglesworth, Karen; Rangarajan, Adithya et al. (2014) Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities. Biol Reprod 91:142
Peng, Jia; Li, Qinglei; Wigglesworth, Karen et al. (2013) Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A 110:E2258
Emori, Chihiro; Wigglesworth, Karen; Fujii, Wataru et al. (2013) Cooperative effects of 17?-estradiol and oocyte-derived paracrine factors on the transcriptome of mouse cumulus cells. Endocrinology 154:4859-72
Lee, Kyung-Bon; Zhang, Meijia; Sugiura, Koji et al. (2013) Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells. Biol Reprod 88:42
Wigglesworth, Karen; Lee, Kyung-Bon; O'Brien, Marilyn J et al. (2013) Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes. Proc Natl Acad Sci U S A 110:E3723-9
Dokshin, Gregoriy A; Baltus, Andrew E; Eppig, John J et al. (2013) Oocyte differentiation is genetically dissociable from meiosis in mice. Nat Genet 45:877-83
Peng, Jia; Li, Qinglei; Wigglesworth, Karen et al. (2013) Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A 110:E776-85
Zhang, Meijia; Su, You-Qiang; Sugiura, Koji et al. (2011) Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro. Endocrinology 152:4377-85

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