Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
7R01HD023924-09
Application #
2199020
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1988-08-01
Project End
2000-03-31
Budget Start
1996-07-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brown University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Fallon, Justin R; McNally, Elizabeth M (2018) Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. Matrix Biol 68-69:616-627
Yilmaz, Atilgan; Kattamuri, Chandramohan; Ozdeslik, Rana N et al. (2016) MuSK is a BMP co-receptor that shapes BMP responses and calcium signaling in muscle cells. Sci Signal 9:ra87
Young, Marian F; Fallon, Justin R (2012) Biglycan: a promising new therapeutic for neuromuscular and musculoskeletal diseases. Curr Opin Genet Dev 22:398-400
Amenta, Alison R; Creely, Hilliary E; Mercado, Mary Lynn T et al. (2012) Biglycan is an extracellular MuSK binding protein important for synapse stability. J Neurosci 32:2324-34
Amenta, Alison R; Yilmaz, Atilgan; Bogdanovich, Sasha et al. (2011) Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice. Proc Natl Acad Sci U S A 108:762-7
Fallon, Justin R (2011) Calcium channels put synapses in their place. Nat Neurosci 14:536-8
Peat, Rachel A; Gecz, Jozef; Fallon, Justin R et al. (2008) Exclusion of biglycan mutations in a cohort of patients with neuromuscular disorders. Neuromuscul Disord 18:606-9
Mercado, Mary Lynn; Amenta, Alison R; Hagiwara, Hiroki et al. (2006) Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS. FASEB J 20:1724-6
Campagna, J A; Fallon, J (2006) Lipid rafts are involved in C95 (4,8) agrin fragment-induced acetylcholine receptor clustering. Neuroscience 138:123-32
Rafii, Michael S; Hagiwara, Hiroki; Mercado, Mary Lynn et al. (2006) Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. J Cell Physiol 209:439-47

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