Abstract

The objective of this application is to establish the effect of perinatal metabolic and hormonal imprinting upon hypothalamic mechanisms regulating appetite.
Aim 1 is to examine the immediate and long-term effects of postnatal ICV administration of NPY or antisense NPY oligonucleotide.
Aim 2 is to examine the immediate and long-term effects of postnatal systemic or ICV administration of insulin and insulin antibody.
Aim 3 is to investigate the postnatal systemic administration of glucose.
Aim 4 is to study the postnatal systemic administration of glucocorticoids on NPY and CRF levels and receptors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD025024-10
Application #
2888970
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1989-07-01
Project End
2002-02-28
Budget Start
1999-08-01
Budget End
2002-02-28
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Calkins, Kara L; Thamotharan, Shanthie; Dai, Yun et al. (2018) Early dietary restriction in rats alters skeletal muscle tuberous sclerosis complex, ribosomal s6 and mitogen-activated protein kinase. Nutr Res 54:93-104
Gibson, Leena Caroline; Shin, Bo-Chul; Dai, Yun et al. (2015) Early leptin intervention reverses perturbed energy balance regulating hypothalamic neuropeptides in the pre- and postnatal calorie-restricted female rat offspring. J Neurosci Res 93:902-12
Freije, William A; Thamotharan, Shanthie; Lee, Regina et al. (2015) The hepatic transcriptome of young suckling and aging intrauterine growth restricted male rats. J Cell Biochem 116:566-79
Garg, Meena; Thamotharan, Manikkavasagar; Becker, Dorothy J et al. (2014) Adolescents with clinical type 1 diabetes display reduced red blood cell glucose transporter isoform 1 (GLUT1). Pediatr Diabetes 15:511-8
Chen, Yongjun; Shin, Bo-Chul; Thamotharan, Shanthie et al. (2014) Differential methylation of the micro-RNA 7b gene targets postnatal maturation of murine neuronal Mecp2 gene expression. Dev Neurobiol 74:407-425
Raychaudhuri, Nupur; Thamotharan, Shanthie; Srinivasan, Malathi et al. (2014) Postnatal exposure to a high-carbohydrate diet interferes epigenetically with thyroid hormone receptor induction of the adult male rat skeletal muscle glucose transporter isoform 4 expression. J Nutr Biochem 25:1066-76
Janzen, C; Lei, M Y Y; Cho, J et al. (2013) Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction. Placenta 34:1072-8
Chen, Pao-Yang; Ganguly, Amit; Rubbi, Liudmilla et al. (2013) Intrauterine calorie restriction affects placental DNA methylation and gene expression. Physiol Genomics 45:565-76
Garg, Meena; Thamotharan, Manikkavasagar; Dai, Yun et al. (2013) Embryo-transfer of the F2 postnatal calorie restricted female rat offspring into a control intra-uterine environment normalizes the metabolic phenotype. Metabolism 62:432-41
Chen, Yongjun; Shin, Bo-Chul; Thamotharan, Shanthie et al. (2013) Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression. Endocrinology 154:1598-611

Showing the most recent 10 out of 22 publications