This is a 4-year application to continue following at 10 and 12 years of age a cohort of very low birthweight (VLBW) and full term (FT) comparison children studied since birth. Maintenance of 77 percent of the original cohort at 8 years allows this study to address important theoretical and clinical issues for a group that presents a major public health problem because of long term developmental deficits. A major objective is to identify the influence of parenting, medical risk factors, and early learning skills on VLBW children's development of self regulation and executive processing (SR/EP) skills that place demands on flexibility in problem solving and behavioral organization. SR/EP skills are a major focus as they are expected to be early origins for the high incidence of behavior problems (e.g., poor attention and impulse control, social immaturity) frequently reported for VLBW children at school age. Deficits in SR/EP skills measured across 3-8 years have been identified for our large cohort of tri-ethnic, socially disadvantaged, medically high risk (HR, n 70) and low risk (LR, n = 106) VLBW vs. FT (n = 104) children. Of importance, relations are found between SR!EP skill growth (3-8 years) and 8 year outcomes requiring more complex aspects of these skills. The major goals for this continuation study are: 1) documenting separate early (i.e., 3, 4, 6, 8 years) and later (8, 10, 12 years) developmental trajectories of SR/EP skills for VLBW and FT children, 2) determining the relations of trajectories to early adolescent outcomes expected to require a strong foundation of development of SR/EP skills, and 3) determining the influence of early and concurrent parenting and child behaviors to later adolescent executive functioning. We are evaluating our cohort of children on a range of more complex SR/EP skills at 8 years (i.e., perspective taking, problem solving with peers, Tower of London, impulse control) and are finding lower scores for the VLBW vs. FT children. We propose to continue to study these same areas of ability at 10 and 12 years of age. By modeling rates of growth from 8-12 years, we can determine if VLBW children show slower growth rates throughout this age range, thus documenting persistent deficits. SR/EP growth trajectories across 3-8 and 8-12 years then will be related to 12 year adolescent outcomes (e.g., deductive reasoning, conflict resolution, friendship network, risk taking, academics, behavior problems). HR and LR VLBW children are expected to display slower growth than FT children and slower growth, in turn, is expected to predict poorer performance on 12-year outcomes. At present, little empirical information is available on the role of SR/EP skill development in understanding VLBW children's later, school age problems.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD025128-12
Application #
6520844
Study Section
Special Emphasis Panel (ZRG1-BBBP-6 (01))
Program Officer
Hanson, James W
Project Start
1994-09-06
Project End
2005-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
12
Fiscal Year
2002
Total Cost
$560,220
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
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Frye, Richard E; Hasan, Khader; Malmberg, Benjamin et al. (2010) Superior longitudinal fasciculus and cognitive dysfunction in adolescents born preterm and at term. Dev Med Child Neurol 52:760-6
Frye, Richard E; Malmberg, Benjamin; Desouza, Laura et al. (2009) Increased prefrontal activation in adolescents born prematurely at high risk during a reading task. Brain Res 1303:111-9
Frye, Richard E; Landry, Susan H; Swank, Paul R et al. (2009) Executive dysfunction in poor readers born prematurely at high risk. Dev Neuropsychol 34:254-71
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Smith, Karen E; Keeney, Susan; Zhang, Lifang et al. (2008) The association of early blood oxygenation with child development in preterm infants with acute respiratory disorders. Int J Dev Neurosci 26:125-31
Smith, Karen E; Landry, Susan H; Swank, Paul R (2006) The role of early maternal responsiveness in supporting school-aged cognitive development for children who vary in birth status. Pediatrics 117:1608-17
Smith, Karen E; Landry, Susan H; Swank, Paul R (2005) The influence of decreased parental resources on the efficacy of a responsive parenting intervention. J Consult Clin Psychol 73:711-20
Assel, M A; Landry, S H; Swank, P R et al. (2002) How do mothers' childrearing histories, stress and parenting affect children's behavioural outcomes? Child Care Health Dev 28:359-68

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