During our initial grant period, we compared a regional sample of 82 extremely low birthweight (ELBW, <750 gram) children to demographically matched groups of very low birthweight (VLBW, 750-1499 gram) and full-term (FT) children. According to the results of assessments of these children at early school age, the ELBW group performed less well than the other two groups on neuropsychological and achievement testing, had more behavior and social problems, and were more often placed in special education programs. Parents of the ELBW children reported higher levels of distress than parents of children in the higher birthweight groups. Health and developmental problems, which are more common in the ELBW group, were also associated with higher rates of psychological symptoms n parents. The purpose of this continuation proposal is to follow these three groups of children as they progress through school. A more recent birth cohort will be added to our sample to investigate outcomes in later-born children and to increase sample size to approximately 100 children per group. A series of four consecutive annual assessments is planned, each involving child and parent assessments similar to those employed in our initial study. The child's health status also will be monitored at each evaluation, and teachers will provide end of year educational status reports. Three hypotheses will be tested. Hypothesis 1 is that ELBW children will acquire skills at a slower rate and show increasing vulnerability to behavior and learning problems with age. Hypothesis 2 is that adverse changes in the child will be accompanied by increasing parent distress and family dysfunction. Hypothesis 3 is that several factors in addition to birthweight will predict age-related changes in child outcomes, including neurosensory and health conditions, developmental and behavioral status at the onset of follow-up, and social-familial variables. Tests of these hypotheses will enhance knowledge of the longer-term consequences of prematurity and of processes accounting for stability or change over time in individual children. Findings also will lead to improved identification of high risk children and will clarify needs for intervention.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD026554-04A2
Application #
2199984
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1993-07-01
Project End
2000-02-29
Budget Start
1995-05-01
Budget End
1996-02-29
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Clark, Caron A C; Fang, Hua; Espy, Kimberly Andrews et al. (2013) Relation of neural structure to persistently low academic achievement: a longitudinal study of children with differing birth weights. Neuropsychology 27:364-377
Taylor, H Gerry; Filipek, Pauline A; Juranek, Jenifer et al. (2011) Brain volumes in adolescents with very low birth weight: effects on brain structure and associations with neuropsychological outcomes. Dev Neuropsychol 36:96-117
Espy, Kimberly Andrews; Fang, Hua; Charak, David et al. (2009) Growth mixture modeling of academic achievement in children of varying birth weight risk. Neuropsychology 23:460-74
Greenley, Rachel Neff; Taylor, H Gerry; Drotar, Dennis et al. (2007) Longitudinal relationships between early adolescent family functioning and youth adjustment: an examination of the moderating role of very low birth weight. J Pediatr Psychol 32:453-62
Moore, Melisa; Gerry Taylor, H; Klein, Nancy et al. (2006) Longitudinal changes in family outcomes of very low birth weight. J Pediatr Psychol 31:1024-35
Peterson, Jennifer; Taylor, H Gerry; Minich, Nori et al. (2006) Subnormal head circumference in very low birth weight children: neonatal correlates and school-age consequences. Early Hum Dev 82:325-34
Litt, Jonathan; Taylor, H Gerry; Klein, Nancy et al. (2005) Learning disabilities in children with very low birthweight: prevalence, neuropsychological correlates, and educational interventions. J Learn Disabil 38:130-41
Filipek, Pauline A; Juranek, Jenifer; Nguyen, Minh T et al. (2004) Relative carnitine deficiency in autism. J Autism Dev Disord 34:615-23
Taylor, H Gerry; Minich, Nori M; Klein, Nancy et al. (2004) Longitudinal outcomes of very low birth weight: neuropsychological findings. J Int Neuropsychol Soc 10:149-63
Taylor, H Gerry; Minich, Nori; Bangert, Barbara et al. (2004) Long-term neuropsychological outcomes of very low birth weight: associations with early risks for periventricular brain insults. J Int Neuropsychol Soc 10:987-1004

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