Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD027468-04A2
Application #
2200450
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1991-08-01
Project End
2000-11-30
Budget Start
1995-12-20
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Ressler, Kerry J; Mercer, Kristina B; Bradley, Bekh et al. (2011) Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470:492-7
May, Victor; Lutz, Eve; MacKenzie, Christopher et al. (2010) Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. J Biol Chem 285:9749-61
Hammack, Sayamwong E; Roman, Carolyn W; Lezak, Kimberly R et al. (2010) Roles for pituitary adenylate cyclase-activating peptide (PACAP) expression and signaling in the bed nucleus of the stria terminalis (BNST) in mediating the behavioral consequences of chronic stress. J Mol Neurosci 42:327-40
Hammack, Sayamwong E; Cheung, Joseph; Rhodes, Kimberly M et al. (2009) Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior. Psychoneuroendocrinology 34:833-43
Braas, Karen M; Schutz, Kristin C; Bond, Jeffrey P et al. (2007) Microarray analyses of pituitary adenylate cyclase activating polypeptide (PACAP)-regulated gene targets in sympathetic neurons. Peptides 28:1856-70
Pavelock, Kristen A; Girard, Beatrice M; Schutz, Kristin C et al. (2007) Bone morphogenetic protein down-regulation of neuronal pituitary adenylate cyclase-activating polypeptide and reciprocal effects on vasoactive intestinal peptide expression. J Neurochem 100:603-16
Girard, Beatrice A; Lelievre, Vincent; Braas, Karen M et al. (2006) Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP- and PACAP-deficient mice. J Neurochem 99:499-513
Girard, Beatrice M; Keller, Emily T; Schutz, Kristin C et al. (2004) Pituitary adenylate cyclase activating polypeptide and PAC1 receptor signaling increase Homer 1a expression in central and peripheral neurons. Regul Pept 123:107-16
Braas, K M; Rossignol, T M; Girard, B M et al. (2004) Pituitary adenylate cyclase activating polypeptide (PACAP) decreases neuronal somatostatin immunoreactivity in cultured guinea-pig parasympathetic cardiac ganglia. Neuroscience 126:335-46
Girard, Beatrice M; May, Victor; Bora, Susan H et al. (2002) Regulation of neurotrophic peptide expression in sympathetic neurons: quantitative analysis using radioimmunoassay and real-time quantitative polymerase chain reaction. Regul Pept 109:89-101

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