Models of regulatory feeding behavior often assume that animals (including humans) eat, and engage in behaviors that are instrumental to obtaining food, in response to interoceptive signals that are correlated with their level of energy need. Accordingly, much research has been devoted to specifying the metabolic and hormonal events that give rise to these types of signals and to specifying the neural substrates involved with their detection and transmission. This work has identified a variety of physiological and pharmacological manipulations that promote or suppress food intake. However, it has been difficult to separate the potential """"""""hunger"""""""" or """"""""satiety"""""""" signal properties of these manipulations from their possible effects on palatability, learning, nonspecific behavioral arousal or other mechanisms that are also known to influence feeding even in the absence of changes in energy need. Integrating methods and concepts from psychobiology and Pavlovian conditioning, the proposed research will develop and exploit a novel model of regulatory feeding behavior that describes how interoceptive signals of energy need act in conjunction with food cues (e.g., tastes and other sensory properties of food) and the postingestive consequences of intake to determine the strength or probability of appetitive and consummatory feeding behavior. Based on studies of Pavlovian conditioned modulation involving conventional auditory and visual stimuli, this model assumes that energy state signals influence feeding behavior by modulating the capacity of food-related stimuli to activate the memory of the appetitive postingestive consequences of intake. New research strategies are proposed to examine the involvement of metabolic, hormonal, subdiaphragmatic vagal, and central nervous system mechanisms in this """"""""memory modulation"""""""" process. In addition, several experiments will assess the nature of the information that animals encode about the foods that they eat as well as the nature of the signals involved with the retrieval/activation of that information. It seems likely that disordered patterns of human feeding behavior involve impairments in the detection, utilization, or modulatory function of energy state signals or in the encoding of information about food. Thus, the proposed research may have important implications with respect to understanding the etiology and developing effective treatments for these disorders.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD028792-08
Application #
6181578
Study Section
Special Emphasis Panel (ZRG1-IFCN-2 (01))
Program Officer
Grave, Gilman D
Project Start
1991-04-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
8
Fiscal Year
2000
Total Cost
$116,701
Indirect Cost
Name
Purdue University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Jones, Sabrina; Sample, Camille H; Hargrave, Sara L et al. (2018) Associative mechanisms underlying the function of satiety cues in the control of energy intake and appetitive behavior. Physiol Behav 192:37-49
Sample, Camille H; Jones, Sabrina; Hargrave, Sara L et al. (2016) Western diet and the weakening of the interoceptive stimulus control of appetitive behavior. Behav Brain Res 312:219-30
Hargrave, Sara L; Jones, Sabrina; Davidson, Terry L (2016) The Outward Spiral: A vicious cycle model of obesity and cognitive dysfunction. Curr Opin Behav Sci 9:40-46
Hargrave, Sara L; Davidson, Terry L; Zheng, Wei et al. (2016) Western diets induce blood-brain barrier leakage and alter spatial strategies in rats. Behav Neurosci 130:123-35
Sample, Camille H; Martin, Ashley A; Jones, Sabrina et al. (2015) Western-style diet impairs stimulus control by food deprivation state cues: Implications for obesogenic environments. Appetite 93:13-23
Hargrave, Sara L; Davidson, Terry L; Lee, Tien-Jui et al. (2015) Brain and behavioral perturbations in rats following Western diet access. Appetite 93:35-43
Davidson, Terry L (2014) Do impaired memory and body weight regulation originate in childhood with diet-induced hippocampal dysfunction? Am J Clin Nutr 99:971-2
Davidson, Terry L; Tracy, Andrea L; Schier, Lindsey A et al. (2014) A view of obesity as a learning and memory disorder. J Exp Psychol Anim Learn Cogn 40:261-79
Martin, Ashley A; Davidson, Terry L (2014) Human cognitive function and the obesogenic environment. Physiol Behav 136:185-93
Davidson, T L; Sample, C H; Swithers, S E (2014) An application of Pavlovian principles to the problems of obesity and cognitive decline. Neurobiol Learn Mem 108:172-84

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