Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD028832-17
Application #
2201352
Study Section
Special Emphasis Panel (ZRG2-END (02))
Project Start
1980-09-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
17
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Tufts University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
073134835
City
Medford
State
MA
Country
United States
Zip Code
02155
Xu, Mingang; McCarrey, John R; Hecht, Norman B (2008) A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells. Nucleic Acids Res 36:7157-67
Yu, Zuoren; Hecht, Norman B (2008) The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability. J Androl 29:572-9
Xu, Mingang; Hecht, Norman B (2008) MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis. Int J Androl 31:457-61
Xu, Mingang; You, Yun; Hunsicker, Patricia et al. (2008) Mice deficient for a small cluster of Piwi-interacting RNAs implicate Piwi-interacting RNAs in transposon control. Biol Reprod 79:51-7
Iguchi, Naoko; Xu, Mingang; Hori, Tamaki et al. (2007) Noncoding RNAs of the mammalian testis: the meiotic transcripts Nct1 and Nct2 encode piRNAs. Ann N Y Acad Sci 1120:84-94
Xu, Mingang; Hecht, Norman B (2007) Polypyrimidine tract binding protein 2 stabilizes phosphoglycerate kinase 2 mRNA in murine male germ cells by binding to its 3'UTR. Biol Reprod 76:1025-33
Stein, Joel M; Bergman, Wayland; Fang, Yanshan et al. (2006) Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J Neurosci 26:2184-96
Iguchi, Naoko; Tobias, John W; Hecht, Norman B (2006) Expression profiling reveals meiotic male germ cell mRNAs that are translationally up- and down-regulated. Proc Natl Acad Sci U S A 103:7712-7
Yu, Zuoren; Raabe, Tobias; Hecht, Norman B (2005) MicroRNA Mirn122a reduces expression of the posttranscriptionally regulated germ cell transition protein 2 (Tnp2) messenger RNA (mRNA) by mRNA cleavage. Biol Reprod 73:427-33
Cho, Yoon Shin; Iguchi, Naoko; Yang, Juxiang et al. (2005) Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis. Biol Reprod 73:840-7

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