Recent advances in microsensor design can be used to refine the technology of intramuscular pressure measurement. The overall objective of this project is to design, develop, and test a fiber optic microsensor which can be used for routine, clinical measurement of muscle function. Currently, the integrated electromyogram is used to indicate the timing and intensity of muscle contraction. However, the problem remains that electromyographic activity cannot provide a quantitative measurement of muscle tension under dynamic conditions. An alternative, measurable parameter related to muscle force is intramuscular pressure. It is thought that intramuscular pressure will account for both active and passive muscle tension. However, currently available intramuscular pressure transducers are too large for optimum comfort. Microsensor technology is now available to construct transducers which are approximately the same size as the fine wires used for electromyographic analysis.
The specific aims of this study are to (1) design and construct a fiber optic microsensor for measuring intramuscular pressure, and (2) determine the relationships between intramuscular pressure, muscle sarcomere length, and muscle tension in an animal model. Successful development of this microsensor will result in a powerful new tool for quantifying muscle function. This device will be useful in offering a better representation of muscle tension under dynamic conditions. It will become an essential tool in clinical gait analysis aimed at improving mobility of disabled patients with neuromuscular disorders such as cerebral palsy, stroke, head injury, spinal cord injury, and poliomyelitis.
| Go, Shanette A; Litchy, William J; Evertz, Loribeth Q et al. (2018) Evaluating skeletal muscle electromechanical delay with intramuscular pressure. J Biomech 76:181-188 |
| Wheatley, Benjamin B; Odegard, Gregory M; Kaufman, Kenton R et al. (2018) Modeling Skeletal Muscle Stress and Intramuscular Pressure: A Whole Muscle Active-Passive Approach. J Biomech Eng 140: |
| Wheatley, Benjamin B; Odegard, Gregory M; Kaufman, Kenton R et al. (2017) A validated model of passive skeletal muscle to predict force and intramuscular pressure. Biomech Model Mechanobiol 16:1011-1022 |
| Go, Shanette A; Jensen, Elisabeth R; O'Connor, Shawn M et al. (2017) Design Considerations of a Fiber Optic Pressure Sensor Protective Housing for Intramuscular Pressure Measurements. Ann Biomed Eng 45:739-746 |
| Wheatley, Benjamin B; Odegard, Gregory M; Kaufman, Kenton R et al. (2017) A case for poroelasticity in skeletal muscle finite element analysis: experiment and modeling. Comput Methods Biomech Biomed Engin 20:598-601 |
| Jensen, Elisabeth R; Morrow, Duane A; Felmlee, Joel P et al. (2016) Characterization of three dimensional volumetric strain distribution during passive tension of the human tibialis anterior using Cine Phase Contrast MRI. J Biomech 49:3430-3436 |
| Wheatley, Benjamin B; Odegard, Gregory M; Kaufman, Kenton R et al. (2016) How does tissue preparation affect skeletal muscle transverse isotropy? J Biomech 49:3056-3060 |
| Evertz, Loribeth Q; Greising, Sarah M; Morrow, Duane A et al. (2016) Analysis of fluid movement in skeletal muscle using fluorescent microspheres. Muscle Nerve 54:444-50 |
| Wheatley, Benjamin B; Morrow, Duane A; Odegard, Gregory M et al. (2016) Skeletal muscle tensile strain dependence: Hyperviscoelastic nonlinearity. J Mech Behav Biomed Mater 53:445-454 |
| Jensen, Elisabeth R; Morrow, Duane A; Felmlee, Joel P et al. (2015) Method of quantifying 3D strain distribution in skeletal muscle using cine phase contrast MRI. Physiol Meas 36:N135-46 |
Showing the most recent 10 out of 25 publications
