Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD033852-08
Application #
6756428
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Taymans, Susan
Project Start
1997-04-01
Project End
2006-04-14
Budget Start
2004-07-01
Budget End
2006-04-14
Support Year
8
Fiscal Year
2004
Total Cost
$241,481
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Tee, Meng Kian; Speek, Mart; Legeza, Balázs et al. (2016) Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2. Mol Cell Endocrinol 434:25-35
McAllister, Jan M; Legro, Richard S; Modi, Bhavi P et al. (2015) Functional genomics of PCOS: from GWAS to molecular mechanisms. Trends Endocrinol Metab 26:118-24
McAllister, Jan M; Modi, Bhavi; Miller, Bruce A et al. (2014) Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. Proc Natl Acad Sci U S A 111:E1519-27
Wickenheisser, Jessica K; Biegler, Jessica M; Nelson-Degrave, Velen L et al. (2012) Cholesterol side-chain cleavage gene expression in theca cells: augmented transcriptional regulation and mRNA stability in polycystic ovary syndrome. PLoS One 7:e48963
Ewens, Kathryn G; Stewart, Douglas R; Ankener, Wendy et al. (2010) Family-based analysis of candidate genes for polycystic ovary syndrome. J Clin Endocrinol Metab 95:2306-15
Wickenheisser, Jessica K; Nelson-DeGrave, Velen L; McAllister, Jan M (2006) Human ovarian theca cells in culture. Trends Endocrinol Metab 17:65-71
Wickenheisser, Jessica K; Nelson-Degrave, Velen L; McAllister, Jan M (2005) Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome. J Clin Endocrinol Metab 90:1720-7
Nelson-Degrave, Velen L; Wickenheisser, Jessica K; Hendricks, Karen L et al. (2005) Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Mol Endocrinol 19:379-90
Wickenheisser, Jessica K; Nelson-DeGrave, Velen L; Hendricks, Karen L et al. (2005) Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. J Clin Endocrinol Metab 90:4858-65
Nelson-DeGrave, Velen L; Wickenheisser, Jessica K; Cockrell, Jennifer E et al. (2004) Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology 145:799-808

Showing the most recent 10 out of 15 publications