Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD033937-10
Application #
6788066
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Kaufman, Steven
Project Start
1995-05-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
10
Fiscal Year
2004
Total Cost
$294,300
Indirect Cost
Name
Yale University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Schatz, Frederick; Guzeloglu-Kayisli, Ozlem; Arlier, Sefa et al. (2016) The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Hum Reprod Update 22:497-515
Guzeloglu Kayisli, Ozlem; Kayisli, Umit A; Basar, Murat et al. (2015) Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding. PLoS One 10:e0137855
Guzel, Elif; Buchwalder, Lynn; Basar, Murat et al. (2015) Effects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells. Gynecol Endocrinol 31:414-8
Shapiro, John P; Basar, Murat; Kayisli, Umit A et al. (2015) Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells. Contraception 91:253-60
Kayisli, Umit A; Basar, Murat; Guzeloglu-Kayisli, Ozlem et al. (2015) Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival. Proc Natl Acad Sci U S A 112:5153-8
Guzeloglu-Kayisli, O; Basar, M; Shapiro, J P et al. (2014) Long-acting progestin-only contraceptives enhance human endometrial stromal cell expressed neuronal pentraxin-1 and reactive oxygen species to promote endothelial cell apoptosis. J Clin Endocrinol Metab 99:E1957-66
Lockwood, Charles J; Basar, Murat; Kayisli, Umit A et al. (2014) Interferon-? protects first-trimester decidual cells against aberrant matrix metalloproteinases 1, 3, and 9 expression in preeclampsia. Am J Pathol 184:2549-59
Lockwood, Charles J; Huang, S Joseph; Chen, Chie-Pein et al. (2013) Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia. Am J Pathol 183:841-56
Lockwood, Charles J; Kayisli, Umit A; Stocco, Carlos et al. (2012) Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells. Am J Pathol 181:2138-48
Krikun, Graciela; Booth, C J; Buchwalder, L et al. (2012) Effects of etonogestrel treatment in the reproductive organs and uterine arteries of nonoophorectomized guinea pigs. Reprod Sci 19:400-6

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