Abstract

Experiments proposed under Specific Aim I deal with basic aspects of placental development and follow directly from published research indicating the importance of the transcription factor AP-2y in regulating placental specific gene expression. Experiments proposed under Specific Aim II deal with the regulation and function of renin at the maternal fetal interface and flow naturally from recent findings concerning renin gene expression during pregnancy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD034130-07
Application #
6387804
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Ilekis, John V
Project Start
1996-05-07
Project End
2005-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
7
Fiscal Year
2001
Total Cost
$285,919
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Elliott, Serra E; Parchim, Nicholas F; Kellems, Rodney E et al. (2016) A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50. Clin Immunol 168:64-71
Luo, Renna; Zhang, Weiru; Zhao, Cheng et al. (2015) Elevated Endothelial Hypoxia-Inducible Factor-1? Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease. Hypertension 66:75-84
Iriyama, Takayuki; Wang, Wei; Parchim, Nicholas F et al. (2015) Hypoxia-independent upregulation of placental hypoxia inducible factor-1? gene expression contributes to the pathogenesis of preeclampsia. Hypertension 65:1307-15
Iriyama, Takayuki; Sun, Kaiqi; Parchim, Nicholas F et al. (2015) Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia. Circulation 131:730-41
Iriyama, Takayuki; Sun, Kaiqi; Parchim, Nicholas F et al. (2015) Response to Letter Regarding Article, ""Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia"". Circulation 132:e222-3
Parchim, Nicholas F; Wang, Wei; Iriyama, Takayuki et al. (2015) Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia. Hypertension 65:430-9
Liu, Chen; Luo, Renna; Elliott, Serra E et al. (2015) Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia. J Am Heart Assoc 4:
Elliott, Serra E; Parchim, Nicholas F; Liu, Chen et al. (2014) Characterization of antibody specificities associated with preeclampsia. Hypertension 63:1086-93
Liu, Chen; Wang, Wei; Parchim, Nicholas et al. (2014) Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification. Hypertension 63:353-61
Wang, Wei; Parchim, Nicholas F; Iriyama, Takayuki et al. (2014) Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia. Hypertension 63:595-606

Showing the most recent 10 out of 39 publications