Abstract

The goal of this research is to elucidate the molecular and cellular mechanisms by which erbB receptors and their ligands influence mammalian development.
Four specific aims are proposed: (1) To determine cellular mechanisms underlying the phenotypes in erbB2-deficient embryos; (2) To examine spatial and temporal expression of neuregulins and their receptors; (3) To determine whether erbB2 is essential for the development and function of other NC cell lineages and organ systems; and (4) To study signal transduction in erbB2-deficient embryos.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD034534-02
Application #
2403622
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Chen, Zhijiang; Donnelly, Christopher R; Dominguez, Bertha et al. (2017) p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep 21:707-720
Hirai, Maretoshi; Arita, Yoh; McGlade, C Jane et al. (2017) Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. J Clin Invest 127:569-582
Xu, Jiqing; de Winter, Fred; Farrokhi, Catherine et al. (2016) Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Sci Rep 6:31692
Vilar, Marçal; Sung, Tsung-Chang; Chen, Zhijiang et al. (2014) Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action. PLoS Biol 12:e1001918
Seidel, Shannon; Bruce, James; Leblanc, Mathias et al. (2013) ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication. Virol J 10:130
Sung, Tsung-Chang; Chen, Zhijiang; Thuret, Sandrine et al. (2013) P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One 8:e69286
Wei, Pei-Chi; Hsieh, Yi-Hsuan; Su, Mei-I et al. (2012) Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell 48:747-59
Morello, Christopher S; Kraynyak, Kimberly A; Levinson, Michael S et al. (2012) Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge. Vaccine 30:6541-6550
Yang, Jiefei; Dominguez, Bertha; de Winter, Fred et al. (2011) Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse. Nat Neurosci 14:324-30
An, Mahru C; Lin, Weichun; Yang, Jiefei et al. (2010) Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A 107:10702-7

Showing the most recent 10 out of 22 publications