Obesity prevention is a top priority of researchers, clinicians, and policy makers. Even young children have not been spared this epidemic, and obesity in young children leads not only to short-term morbidity but also to later obesity and its adverse consequences. Thus it is critical to identify modifiable determinants of obesity that exist very early in life, even before birth. In this proposed competing continuation of R01 HD34568, our overall goal is to examine the roles of prenatal dietary and hormonal factors, infant feeding, and postnatal growth in the genesis of adiposity-related outcomes at the age of 7 ears. The main study outcomes will be total and regional fat mass assessed by dual x-ray absorptiometry (DXA), and plasma adiponectin levels. This study will extend and amplify a body of work from the first five years of funding for Project Viva, a prospective longitudinal study of pregnant women and their children. While some studies have examined associations of birth weight with later obesity, birth weight is but a momentary marker, an integral of numerous determinants operating before birth. In this proposal, we will """"""""go beyond birth weight"""""""" to focus on two endocrine factors operating prenatally. glucocorticoids and leptin. as well as maternal intake of long- chain polvunsaturated fatty acids, that could be involved in the development of obesity in the offspring. The role of breastfeeding in obesity prevention has taken on new urgency in the 21st century. In this study, we will address the validity of epidemiologic associations between breastfeeding and later adiposity-related outcomes, both by carefully controlling for potential confounding by sociocultural factors and by evaluating plausible mechanisms, including behavioral and metabolic effects. We will also address the extent to which any associations of accelerated infant growth with later adiposity can be ascribed to metabolic pathways operating prenatally or to infant feeding practice. By following to age 7 years participants originally recruited prenatally and followed prospectively as part of Project Viva, the proposed project is uniquely poised to examine events occurring in the pre- and peri-natal period as critical to the development of obesity in childhood. The results of this study promise to unravel some knotty epidemiologic issues in the early origins of obesity, and to open up new potential avenues for primordial obesity prevention. ? ? ? ?

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1-KNOD-N (01))
Program Officer
Grave, Gilman D
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Harvard Pilgrim Health Care, Inc.
United States
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Peng, Cheng; den Dekker, Martijn; Cardenas, Andres et al. (2018) Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). Environ Health Perspect 126:97006
Cohen, Juliana F W; Rifas-Shiman, Sheryl L; Young, Jessica et al. (2018) Associations of Prenatal and Child Sugar Intake With Child Cognition. Am J Prev Med 54:727-735
Perng, Wei; Rifas-Shiman, Sheryl L; Hivert, Marie-France et al. (2018) Branched Chain Amino Acids, Androgen Hormones, and Metabolic Risk Across Early Adolescence: A Prospective Study in Project Viva. Obesity (Silver Spring) 26:916-926
Kelly, R S; Sordillo, J E; Lasky-Su, J et al. (2018) Plasma metabolite profiles in children with current asthma. Clin Exp Allergy 48:1297-1304
Cespedes Feliciano, Elizabeth M; Quante, Mirja; Rifas-Shiman, Sheryl L et al. (2018) Objective Sleep Characteristics and Cardiometabolic Health in Young Adolescents. Pediatrics 142:
Fulay, Aarohee P; Rifas-Shiman, Sheryl L; Oken, Emily et al. (2018) Associations of the dietary approaches to stop hypertension (DASH) diet with pregnancy complications in Project Viva. Eur J Clin Nutr 72:1385-1395
Mora, Ana M; Fleisch, Abby F; Rifas-Shiman, Sheryl L et al. (2018) Early life exposure to per- and polyfluoroalkyl substances and mid-childhood lipid and alanine aminotransferase levels. Environ Int 111:1-13
Maslova, Ekaterina; Rifas-Shiman, Sheryl L; Olsen, Sjurdur F et al. (2018) Prenatal n-3 long-chain fatty acid status and offspring metabolic health in early and mid-childhood: results from Project Viva. Nutr Diabetes 8:29
Harris, Maria H; Oken, Emily; Rifas-Shiman, Sheryl L et al. (2018) Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFASs) and child cognition. Environ Int 115:358-369
Tripathi, Ruby Reetika; Rifas-Shiman, Sheryl L; Hawley, Nicola et al. (2018) Hypertensive Disorders of Pregnancy and Offspring Cardiometabolic Health at Midchildhood: Project Viva Findings. J Am Heart Assoc 7:

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