Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD038572-12
Application #
6637394
Study Section
Mammalian Genetics Study Section (MGN)
Program Officer
Moody, Sally Ann
Project Start
2000-03-01
Project End
2005-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
12
Fiscal Year
2003
Total Cost
$335,189
Indirect Cost
Name
Nationwide Children's Hospital
Department
Type
DUNS #
147212963
City
Columbus
State
OH
Country
United States
Zip Code
43205
Gabitova, Linara; Restifo, Diana; Gorin, Andrey et al. (2015) Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep 12:1927-38
Cunningham, David; DeBarber, Andrea E; Bir, Natalie et al. (2015) Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Hum Mol Genet 24:2808-25
Sukhanova, Anna; Gorin, Andrey; Serebriiskii, Ilya G et al. (2013) Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov 3:96-111
Porter, Forbes D; Herman, Gail E (2011) Malformation syndromes caused by disorders of cholesterol synthesis. J Lipid Res 52:6-34
Cunningham, David; Spychala, Kaitlyn; McLarren, Keith W et al. (2009) Developmental expression pattern of the cholesterogenic enzyme NSDHL and negative selection of NSDHL-deficient cells in the heterozygous Bpa(1H)/+ mouse. Mol Genet Metab 98:356-66
Jiang, Fenglei; Herman, Gail E (2006) Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet 15:3293-305
Cunningham, David; Swartzlander, Daniel; Liyanarachchi, Sandya et al. (2005) Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts. J Lipid Res 46:1150-62
Caldas, Hugo; Cunningham, David; Wang, Xiaojian et al. (2005) Placental defects are associated with male lethality in bare patches and striated embryos deficient in the NAD(P)H Steroid Dehydrogenase-like (NSDHL) Enzyme. Mol Genet Metab 84:48-60
Herman, Gail E (2003) Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet 12 Spec No 1:R75-88
Hummel, Marybeth; Cunningham, David; Mullett, Charles J et al. (2003) Left-sided CHILD syndrome caused by a nonsense mutation in the NSDHL gene. Am J Med Genet A 122A:246-51

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