Abstract

The specific objective of this research project is to evaluate the factors which contribute to the regulation of the heart peripheral circulation. This involves evaluating the relative contribution of neural reflexes from the arterial baroreceptor, cardiopulmonary receptors and autoregulation. Animal models include conscious dogs and anesthetized cats. Studies include the identification of neural pathways regulating the cardiovascular response to acute myocardial ischemia and the interaction of reflexes arising from the cardiopulmonary and arterial baroreceptors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL012415-16
Application #
3334469
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1975-02-01
Project End
1986-09-30
Budget Start
1985-07-01
Budget End
1986-09-30
Support Year
16
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
School of Medicine & Dentistry
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Sanderford, Max G; Bishop, Vernon S (2002) Central mechanisms of acute ANG II modulation of arterial baroreflex control of renal sympathetic nerve activity. Am J Physiol Heart Circ Physiol 282:H1592-602
Sanderford, M G; Bishop, V S (2000) Angiotensin II acutely attenuates range of arterial baroreflex control of renal sympathetic nerve activity. Am J Physiol Heart Circ Physiol 279:H1804-12
Nishida, Y; Sugimoto, I; Morita, H et al. (1998) Suppression of renal sympathetic nerve activity during portal vein infusion of hypertonic saline. Am J Physiol 274:R97-103
Farrell, D M; Bishop, V S (1997) The roles of cGMP and cAMP in active thermoregulatory vasodilation. Am J Physiol 272:R975-81
Nishida, Y; Hosomi, H; Bishop, V S (1997) Long-term effects of AVP-induced neurohumoral interaction via area postrema on body fluid and blood pressure. Am J Physiol 273:R1696-703
Qu, L; Hay, M; Bishop, V S (1997) Administration of AVP to the area postrema alters response of NTS neurons to afferent inputs. Am J Physiol 272:R519-25
Ryuzaki, M; Stahl, L K; Lyson, T et al. (1997) Sympathoexcitatory response to cyclosporin A and baroreflex resetting. Hypertension 29:576-82
DiCarlo, S E; Stahl, L K; Bishop, V S (1997) Daily exercise attenuates the sympathetic nerve response to exercise by enhancing cardiac afferents. Am J Physiol 273:H1606-10
Ryan, K L; Taylor, W F; Bishop, V S (1997) Arterial baroreflex modulation of heat-induced vasodilation in the rabbit ear. J Appl Physiol 83:2091-7
Cai, Y; Hay, M; Bishop, V S (1996) Synaptic connections and interactions between area postrema and nucleus tractus solitarius. Brain Res 724:121-4

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