Abstract

The role of vasopressin in the control of renal water excretion has long been known. Evidence developed in recent years suggests that vasopressin may also be important in the physiological control of the cardiovascular system, and these has been considerable interest in the possible participation of vasopressin in the pathogenesis of some forms of clinical and experimental hypertension. It has been the long-term objective of this research program to identify and study the factors which determine the plasma concentration of vasopressin. The present application is concerned with the role of brain neurotransmitters and neuromodulators involved in the stimulation of vasopressin release by increased plasma osmolality and by decreased blood volume and blood pressure. Brain prostanoids appear to play an important role in the osmotic and volume-pressure control of vasopressin release, by modulating the activity of the relevant neurotransmitters or by direct actions on the vasopressinergic neurosecretory cells. It is proposed to test this hypothesis and to identify the brain neurotransmitters involved in this control and the sites in the brain where these actions occur.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL012990-20
Application #
3334559
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1977-12-01
Project End
1991-09-14
Budget Start
1989-09-15
Budget End
1990-09-14
Support Year
20
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Tennessee Health Science Center
Department
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163

  Publications

He, X R; Wang, W; Crofton, J T et al. (1999) Effects of 17beta-estradiol on the baroreflex control of sympathetic activity in conscious ovariectomized rats. Am J Physiol 277:R493-8
He, X R; Wang, W; Crofton, J T et al. (1998) Effects of 17beta-estradiol on sympathetic activity and pressor response to phenylephrine in ovariectomized rats. Am J Physiol 275:R1202-8
Crofton, J T; Share, L (1997) Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29:494-9
Wang, Y X; Crofton, J T; Share, L (1997) Sex differences in the cardiovascular and renal actions of vasopressin in conscious rats. Am J Physiol 272:R370-6
Wang, Y X; Crofton, J T; Bealer, S L et al. (1997) Sexual dimorphism in regional blood flow responses to vasopressin in conscious rats. Am J Physiol 273:R1126-31
Wang, Y X; Crofton, J T; Liu, H et al. (1996) V2-receptor blockade enhances pressor response to vasopressin: gender difference. Life Sci 59:695-703
Wang, Y X; Crofton, J T; Miller, J et al. (1996) Sex difference in urinary concentrating ability of rats with water deprivation. Am J Physiol 270:R550-5
Liu, H W; Wang, Y X; Crofton, J T et al. (1996) Central vasopressin blockade enhances its peripheral release in response to peripheral osmotic stimulation in conscious rats. Brain Res 719:14-22
Wang, Y X; Crofton, J T; Liu, H et al. (1995) Estradiol attenuates the antidiuretic action of vasopressin in ovariectomized rats. Am J Physiol 268:R951-7
Sato, K; Crofton, J T; Wang, Y X et al. (1995) Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat. Brain Res 689:71-8

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