Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL017921-19S1
Application #
3335486
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1991-04-01
Project End
1996-03-31
Budget Start
1993-04-01
Budget End
1994-03-31
Support Year
19
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Yin, Huiyong; Davis, Todd; Porter, Ned A (2010) Simultaneous analysis of multiple lipid oxidation products in vivo by liquid chromatographic-mass spectrometry (LC-MS). Methods Mol Biol 610:375-86
Nam, Tae-Gyu; Nara, Susheel J; Zagol-Ikapitte, Irene et al. (2009) Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org Biomol Chem 7:5103-12
Yin, Huiyong; Porter, Ned A (2007) Identification of intact lipid peroxides by Ag+ coordination ion-spray mass spectrometry (CIS-MS). Methods Enzymol 433:193-211
Yin, Huiyong; Gao, Ling; Tai, Hsin-Hsiung et al. (2007) Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem 282:329-36
Furse, Kristina E; Pratt, Derek A; Porter, Ned A et al. (2006) Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behavior. Biochemistry 45:3189-205
Furse, Kristina E; Pratt, Derek A; Schneider, Claus et al. (2006) Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Biochemistry 45:3206-18
Yin, Huiyong; Porter, Ned A (2005) New insights regarding the autoxidation of polyunsaturated fatty acids. Antioxid Redox Signal 7:170-84
Milne, Ginger L; Seal, Jennifer R; Havrilla, Christine M et al. (2005) Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J Lipid Res 46:307-19
Punta, Carlo; Rector, Christopher L; Porter, Ned A (2005) Peroxidation of polyunsaturated fatty acid methyl esters catalyzed by N-methyl benzohydroxamic acid: a new and convenient method for selective synthesis of hydroperoxides and alcohols. Chem Res Toxicol 18:349-56
Yin, Huiyong; Musiek, Erik S; Gao, Ling et al. (2005) Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. J Biol Chem 280:26600-11

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