Little is known about the etiology of individual differences in psychological development during middle childhood, an era marked by changes in cognitive and social behavior nearly as dramatic as those seen during the transition from infancy to early childhood or during adolescence. The proposed research will apply the most powerful quantitative (biometrical) genetic methodology, the """"""""full"""""""" adoption design in which data are collected from both birth and adoptive parents, to the study of psychological development in 7-year-olds. The sample is unique: over 400 adopted and matched nonadopted children who previously have been studied in their homes at 1, 2, 3, and 4 years of age using an extensive set of psychological and environmental assessments. The birth parents and adoptive parents of the adoptees and the parents of the nonadopted children have been administered a 3-hour battery of psychological measures. The proposed 5-year project will provide for testing the 7-year-old adopted and nonadopted children on a multidimensional battery of psychological measures including general and specific cognitive abilities, communicative skills, school achievement, temperament, behavioral problems, motoric development, and social interaction. The project will capitalize on the potent design and the extensive data set previously collected as part of the Colorado Adoption Project in applying multivariate, longitudinal, and quatitative genetic analyses to data obtained during the important developmental period marked by the beginning of formal schooling. The results of these analyses, which will substantially advance our understanding of the etiology of individual differences in functioning during this critical epoch, are likely to have important implications for childrearing, education, and mental health.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL018426-27
Application #
6182856
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1988-09-30
Project End
2001-11-30
Budget Start
2000-08-01
Budget End
2001-11-30
Support Year
27
Fiscal Year
2000
Total Cost
$281,221
Indirect Cost
Name
Tulane University
Department
Physiology
Type
Schools of Medicine
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Dobrowolski, Leszek; Kuczeriszka, Marta; Castillo, Alexander et al. (2015) Role of atrial natriuretic peptide in mediating the blood pressure-independent natriuresis elicited by systemic inhibition of nitric oxide. Pflugers Arch 467:833-41
Navar, L Gabriel (2014) Intrarenal renin-angiotensin system in regulation of glomerular function. Curr Opin Nephrol Hypertens 23:38-45
Navar, L Gabriel; Satou, Ryousuke; Gonzalez-Villalobos, Romer A (2012) The increasing complexity of the intratubular Renin-Angiotensin system. J Am Soc Nephrol 23:1130-2
Green, Torrance; Gonzalez, Alexis A; Mitchell, Kenneth D et al. (2012) The complex interplay between cyclooxygenase-2 and angiotensin II in regulating kidney function. Curr Opin Nephrol Hypertens 21:7-14
Zhao, Di; Zhang, Jin; Blaustein, Mordecai P et al. (2011) Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na+/Ca2+ exchanger knockout mice. Am J Physiol Renal Physiol 301:F574-9
Jackson, Keith E; Jackson, Debra W; Quadri, Syed et al. (2011) Inhibition of heme oxygenase augments tubular sodium reabsorption. Am J Physiol Renal Physiol 300:F941-6
Kopkan, Libor; Hess, Arthur; Huskova, Zuzana et al. (2010) High-salt intake enhances superoxide activity in eNOS knockout mice leading to the development of salt sensitivity. Am J Physiol Renal Physiol 299:F656-63
Feng, Ming-Guo; Navar, L Gabriel (2010) Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol 299:F310-5
Zhao, Di; Pandey, Kailash N; Navar, L Gabriel (2010) ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptor. Am J Physiol Renal Physiol 298:F103-8
LeBlanc, Ryan M; Navar, L Gabriel; Botros, Fady T (2010) Bilirubin exerts renoprotective effects in angiotensin II-hypertension. Am J Med Sci 340:144-6

Showing the most recent 10 out of 97 publications