Abstract

This proposal is a continuation of 15 years' of research with the goal to understand the pathophysiology of myocardial ischemia and reperfusion (I/R) particularly as it applies to myocardial protection. It has become evident that coronary endothelium is a critical component in maintaining normal myocardial function. Endothelial cells play a significant role in preventing and exasperating injury related to ischemia and reperfusion. Multiple factors need to be studied including nitric oxide, prostacyclin, endothelin and angiotensin-II. Attempts will be made to understand the interaction of the beneficial and toxic factors. The models to be used to study these intracellular-generated endogenous factors will include rat and swine heart models. These factors will be studied during both global and regional ischemia/reperfusion. The regulatory mechanisms will be studied with particular attention to calcium flux. The approach will be clinically oriented toward cardiac surgery for ischemia involving the territory of the left anterior descending artery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL022559-16A2
Application #
2028035
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1979-08-01
Project End
2000-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
16
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Das, Somak; Mitrovsky, Goran; Vasanthi, Hannah R et al. (2014) Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxid Med Cell Longev 2014:345105
Das, Somak; Mukherjee, Subhendu; Lekli, Istvan et al. (2012) Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem 360:35-45
(2012) Retraction. Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem 60:2766
Mukhopadhyay, Partha; Pacher, Pal; Das, Dipak K (2011) MicroRNA signatures of resveratrol in the ischemic heart. Ann N Y Acad Sci 1215:109-16
Das, Dipak K; Mukherjee, Subhendu; Ray, Diptarka (2011) Erratum to: resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 16:425-35
Juhasz, Bela; Juhaz, Bela; Das, Dipak K et al. (2011) Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, longevinex. [corrected] Mol Cell Biochem 348:199-203
Gurusamy, Narasimman; Lekli, Istvan; Mukherjee, Subhendu et al. (2010) Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res 86:103-12
Lekli, Istvan; Ray, Diptarka; Mukherjee, Subhendu et al. (2010) Co-ordinated autophagy with resveratrol and ?-tocotrienol confers synergetic cardioprotection. J Cell Mol Med 14:2506-18
Mukherjee, Subhendu; Lekli, Istvan; Ray, Diptarka et al. (2010) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. Br J Nutr 103:815-23
Lekli, I; Mukherjee, S; Ray, D et al. (2010) Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FoxO-signaling network. Gene Ther 17:478-85

Showing the most recent 10 out of 253 publications