Abstract

This proposal is a continuation of 15 years' of research with the goal to understand the pathophysiology of myocardial ischemia and reperfusion (I/R) particularly as it applies to myocardial protection. It has become evident that coronary endothelium is a critical component in maintaining normal myocardial function. Endothelial cells play a significant role in preventing and exasperating injury related to ischemia and reperfusion. Multiple factors need to be studied including nitric oxide, prostacyclin, endothelin and angiotensin-II. Attempts will be made to understand the interaction of the beneficial and toxic factors. The models to be used to study these intracellular-generated endogenous factors will include rat and swine heart models. These factors will be studied during both global and regional ischemia/reperfusion. The regulatory mechanisms will be studied with particular attention to calcium flux. The approach will be clinically oriented toward cardiac surgery for ischemia involving the territory of the left anterior descending artery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL022559-18
Application #
2901033
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1979-08-01
Project End
2000-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
18
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Das, Somak; Mitrovsky, Goran; Vasanthi, Hannah R et al. (2014) Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxid Med Cell Longev 2014:345105
Das, Somak; Mukherjee, Subhendu; Lekli, Istvan et al. (2012) Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem 360:35-45
(2012) Retraction. Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem 60:2766
Mukhopadhyay, Partha; Pacher, Pal; Das, Dipak K (2011) MicroRNA signatures of resveratrol in the ischemic heart. Ann N Y Acad Sci 1215:109-16
Das, Dipak K; Mukherjee, Subhendu; Ray, Diptarka (2011) Erratum to: resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 16:425-35
Juhasz, Bela; Juhaz, Bela; Das, Dipak K et al. (2011) Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, longevinex. [corrected] Mol Cell Biochem 348:199-203
Gurusamy, Narasimman; Lekli, Istvan; Ahsan, Md Kaimul et al. (2010) Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. FEBS Lett 584:187-93
Das, Dipak K; Mukherjee, Subhendu; Ray, Diptarka (2010) Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 15:467-77
Vasanthi, Hannah Rachel; Mukherjee, Subhendu; Ray, Diptarka et al. (2010) Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. Food Funct 1:278-83
Gurusamy, Narasimman; Lekli, Istvan; Mukherjee, Subhendu et al. (2010) Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway. Cardiovasc Res 86:103-12

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