Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL023632-14S1
Application #
3337342
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1980-12-01
Project End
1995-06-30
Budget Start
1993-07-01
Budget End
1994-06-30
Support Year
14
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Oregon State University
Department
Type
Schools of Arts and Sciences
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
Mosser, Valerie A; Amana, Ian J; Schimerlik, Michael I (2002) Kinetic analysis of M2 muscarinic receptor activation of Gi in Sf9 insect cell membranes. J Biol Chem 277:922-31
Vogel, W K; Peterson, G L; Broderick, D J et al. (1999) Double mutant cycle analysis of aspartate 69, 97, and 103 to asparagine mutants in the m2 muscarinic acetylcholine receptor. Arch Biochem Biophys 361:283-94
Vogel, W K; Sheehan, D M; Schimerlik, M I (1997) Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling. Mol Pharmacol 52:1087-94
Bulseco, D A; Schimerlik, M I (1996) Single amino acid substitutions in the pm2 muscarinic receptor alter receptor/G protein coupling without changing physiological responses. Mol Pharmacol 49:132-41
Vogel, W K; Mosser, V A; Bulseco, D A et al. (1995) Porcine m2 muscarinic acetylcholine receptor-effector coupling in Chinese hamster ovary cells. J Biol Chem 270:15485-93
Hirschberg, B T; Mosser, V A; Peterson, G L et al. (1995) Kinetic and biophysical analysis of the m2 muscarinic receptor. Life Sci 56:907-13
Peterson, G L; Toumadje, A; Johnson Jr, W C et al. (1995) Purification of recombinant porcine m2 muscarinic acetylcholine receptor from Chinese hamster ovary cells. Circular dichroism spectra and ligand binding properties. J Biol Chem 270:17808-14
Huang, S C; Fortune, K P; Wank, S A et al. (1994) Multiple affinity states of different cholecystokinin receptors. J Biol Chem 269:26121-6
Tota, M R; Schimerlik, M I (1990) Partial agonist effects on the interaction between the atrial muscarinic receptor and the inhibitory guanine nucleotide-binding protein in a reconstituted system. Mol Pharmacol 37:996-1004
Tota, M R; Xia, Z Q; Storm, D R et al. (1990) Reconstitution of muscarinic receptor-mediated inhibition of adenylyl cyclase. Mol Pharmacol 37:950-7

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