Abstract

The influence of forebrain area involed primarily in the control of body fluid volumes on experimental hypertension will be assessed. Studies include examination of the effect of destruction of this area on the development of experimental hypertension, the effects of chronic stimulation of this area with hormones or osmotic stimuli, and the effect of inhibition or stimulation of the area on cardiovascular reflexes originating in the heart (reflexes involved in sensing alterations in blood volume).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL024111-07
Application #
3337522
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1979-07-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Michigan State University
Department
Type
Schools of Osteopathy
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

Xu, Hui; Fink, Gregory D; Galligan, James J (2007) Increased sympathetic venoconstriction and reactivity to norepinephrine in mesenteric veins in anesthetized DOCA-salt hypertensive rats. Am J Physiol Heart Circ Physiol 293:H160-8
Xu, Hui; Jackson, William F; Fink, Gregory D et al. (2006) Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats. Hypertension 48:1080-7
Xu, Hui; Bian, Xiaochun; Watts, Stephanie W et al. (2005) Activation of vascular BK channel by tempol in DOCA-salt hypertensive rats. Hypertension 46:1154-62
Xu, Hui; Fink, Gregory D; Galligan, James J (2004) Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. Hypertension 43:329-34
Luo, Min; Hess, Margaret C; Fink, Gregory D et al. (2003) Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats. Auton Neurosci 104:47-57
Johnson, Ronald J; Fink, Gregory D; Watts, Stephanie W et al. (2002) Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats. J Hypertens 20:665-76
Xu, Hui; Fink, Gregory D; Galligan, James J (2002) Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats. Am J Physiol Heart Circ Physiol 283:H885-92
Johnson, R J; Galligan, J J; Fink, G D (2001) Effect of an ET(B)-selective and a mixed ET(A/B) endothelin receptor antagonist on venomotor tone in deoxycorticosterone-salt hypertension. J Hypertens 19:431-40
Johnson, R J; Galligan, J J; Fink, G D (2001) Factors affecting endothelin-induced venous tone in conscious rats. J Cardiovasc Pharmacol 37:187-95
Ballew, J R; Fink, G D (2001) Role of endothelin ETB receptor activation in angiotensin II-induced hypertension: effects of salt intake. Am J Physiol Heart Circ Physiol 281:H2218-25

Showing the most recent 10 out of 41 publications