Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL024415-16S1
Application #
2215755
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1979-07-01
Project End
1996-12-31
Budget Start
1994-07-15
Budget End
1995-06-30
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Cui, Shuaiying; Tanabe, Osamu; Sierant, Michael et al. (2015) Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic ?-type globin genes. Blood 125:1477-87
Cui, Shuaiying; Lim, Kim-Chew; Shi, Lihong et al. (2015) The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood 126:386-96
Shi, Lihong; Sierant, M C; Gurdziel, Katherine et al. (2014) Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet 10:e1004339
Shi, Lihong; Lin, Yu-Hsuan; Sierant, M C et al. (2014) Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet 23:4528-42
Cui, Shuaiying; Tanabe, Osamu; Lim, Kim-Chew et al. (2014) PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol 34:1956-65
Hosoya, Tomonori; Clifford, Mary; Losson, RĂ©gine et al. (2013) TRIM28 is essential for erythroblast differentiation in the mouse. Blood 122:3798-807
Suzuki, Mikiko; Yamazaki, Hiromi; Mukai, Harumi Y et al. (2013) Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model. Mol Cell Biol 33:1687-95
Shi, Lihong; Cui, Shuaiying; Engel, James D et al. (2013) Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med 19:291-4
Campbell, Andrew D; Cui, Shuaiying; Shi, Lihong et al. (2011) Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A 108:18808-13
Cui, Shuaiying; Kolodziej, Katarzyna E; Obara, Naoshi et al. (2011) Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic ?-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol 31:3298-311

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