Abstract

The proposed research is directed toward understanding the effect of the physiological environment on the degradation of polymeric biomaterials. Accelerated in vivo and in vitro methods will be used to study biodegradation of polyurethane elastomers used in cardiovascular applications. Procedures for an accelerated in vivo biodegradation test will be developed using chemotactic peptides. Temporal variations of enzyme levels and inflammatory cells in the exudate will be correlated with observed property changes. A model poly(alpha-amino acid) elastomer will be used to gain a fundamental understanding of the enzyme degradation mechanism. Stress-enhancement is proposed as a new method of accelerated in vitro testing. This method is also relevant to many end use applications of the materials chosen for investigation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL025239-08
Application #
3338005
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1979-12-01
Project End
1991-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Dadsetan, Mahrokh; Jones, Jacqueline A; Hiltner, Anne et al. (2004) Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages. J Biomed Mater Res A 71:439-48
Wiggins, Michael J; Anderson, James M; Hiltner, Anne (2003) Biodegradation of polyurethane under fatigue loading. J Biomed Mater Res A 65:524-35
Wiggins, Michael J; Anderson, James M; Hiltner, Anne (2003) Effect of strain and strain rate on fatigue-accelerated biodegradation of polyurethane. J Biomed Mater Res A 66:463-75
Dadsetan, M; Christenson, E M; Unger, F et al. (2003) In vivo biocompatibility and biodegradation of poly(ethylene carbonate). J Control Release 93:259-70
Wiggins, M J; Wilkoff, B; Anderson, J M et al. (2001) Biodegradation of polyether polyurethane inner insulation in bipolar pacemaker leads. J Biomed Mater Res 58:302-7
Kao, W J (2000) Evaluation of leukocyte adhesion on polyurethanes: the effects of shear stress and blood proteins. Biomaterials 21:2295-303
Kao, W J (1999) Evaluation of protein-modulated macrophage behavior on biomaterials: designing biomimetic materials for cellular engineering. Biomaterials 20:2213-21
Collier, T; Tan, J; Shive, M et al. (1998) Biocompatibility of poly(etherurethane urea) containing dehydroepiandrosterone. J Biomed Mater Res 41:192-201
Schubert, M A; Wiggins, M J; Anderson, J M et al. (1997) The effect of strain state on the biostability of a poly(etherurethane urea) elastomer. J Biomed Mater Res 35:319-28
Sapatnekar, S; Kao, W J; Anderson, J M (1997) Leukocyte-biomaterial interactions in the presence of Staphylococcus epidermidis: flow cytometric evaluation of leukocyte activation. J Biomed Mater Res 35:409-20

Showing the most recent 10 out of 48 publications