19-Nor deoxycorticosterone (19-nor-DOC) is a recently identified powerful nineralocorticoid. We have found that the urinary excretation of 19-nor-DOC is increased in rats with adrenal regeneration hpertension and others have found it markedly elevated in the pre-hypertensive stage of the spontaneously hypertensive rat (SHR). We propose to study the chronology of increased excretion rates of 19-nor-DOC in the urine and the precursor, 19-oic-DOC, in the plasma of rats during the development of ARH. The adrenal synthesis and regulation of 19-oic DOC will also be studied using in vivo and in vitro techniques. The peripheral conversion of 19-oic-DOC into 19-nor-DOC will also be studied by incubating various organs with (3H)-19-oic-DOC and measuring the formation of (3H)-19-nor-DOC. In addition, the role of 19-nor-DOC in the pathogenesis of two types of genetic hpertension, the SHR and Dahl's S & R strains of rats. Finally, we will search for the presence of other 19-oic-steroids in adrenal incubations. As standard methods of steroids almost guarantee the elimination of this type of steroid, it is not surprising that they have not been previously isolated.
| Gomez-Sanchez, Elise P (2016) Third-generation Mineralocorticoid Receptor Antagonists: Why Do We Need a Fourth? J Cardiovasc Pharmacol 67:26-38 |
| Gomez-Sanchez, Elise P (2015) Salt-sensitive hypertension: food for thought. Hypertension 65:283-4 |
| Gomez-Sanchez, Elise; Gomez-Sanchez, Celso E (2014) The multifaceted mineralocorticoid receptor. Compr Physiol 4:965-94 |
| Gomez-Sanchez, Elise P (2014) Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis. Steroids 91:20-31 |
| Gomez-Sanchez, Elise P; Gomez-Sanchez, Celso E (2012) Central regulation of blood pressure by the mineralocorticoid receptor. Mol Cell Endocrinol 350:289-98 |
| Gomez-Sanchez, Elise P (2011) Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule? Trends Endocrinol Metab 22:179-87 |
| Gomez Sanchez, Elise P (2009) Central mineralocorticoid receptors and cardiovascular disease. Neuroendocrinology 90:245-50 |
| Gomez-Sanchez, Elise P; Samuel, Jacqueline; Vergara, Gaston et al. (2005) Effect of 3beta-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat. Am J Physiol Regul Integr Comp Physiol 288:R389-93 |
| Gomez-Sanchez, Elise P; Ahmad, Naveed; Romero, Damian G et al. (2005) Is aldosterone synthesized within the rat brain? Am J Physiol Endocrinol Metab 288:E342-6 |
| Gomez-Sanchez, Elise P; Ahmad, Naveed; Romero, Damian G et al. (2004) Origin of aldosterone in the rat heart. Endocrinology 145:4796-802 |
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