Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL029305-14
Application #
2216432
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1983-04-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Birkenmeier, Connie S; Barker, Jane E (2004) Hereditary haemolytic anaemias: unexpected sequelae of mutations in the genes for erythroid membrane skeletal proteins. J Pathol 204:450-9
Wandersee, Nancy J; Olson, Scott C; Holzhauer, Sandra L et al. (2004) Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis. Blood 103:710-6
Wandersee, Nancy J; Birkenmeier, Connie S; Bodine, David M et al. (2003) Mutations in the murine erythroid alpha-spectrin gene alter spectrin mRNA and protein levels and spectrin incorporation into the red blood cell membrane skeleton. Blood 101:325-30
Wandersee, N J; Lee, J C; Deveau, S A et al. (2001) Reduced incidence of thrombosis in mice with hereditary spherocytosis following neonatal treatment with normal hematopoietic cells. Blood 97:3972-5
Wandersee, N J; Roesch, A N; Hamblen, N R et al. (2001) Defective spectrin integrity and neonatal thrombosis in the first mouse model for severe hereditary elliptocytosis. Blood 97:543-50
Peters, L L; Lane, P W; Andersen, S G et al. (2001) Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency. Blood Cells Mol Dis 27:850-60
Wandersee, N J; Tait, J F; Barker, J E (2000) Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia. Blood Cells Mol Dis 26:75-83
Barker, J E; Deveau, S; Wandersee, N J (2000) Amelioration of severe hereditary spherocytosis in nonablated adult mice by marrow transplantation. Exp Hematol 28:985-92
Dooner, G J; Barker, J E; Gallagher, P G et al. (2000) Gene transfer to ankyrin-deficient bone marrow corrects spherocytosis in vitro. Exp Hematol 28:765-74
Wandersee, N J; Birkenmeier, C S; Gifford, E J et al. (2000) Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene. Hematol J 1:235-42

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