Experiments are described to determine the cardiovascular control mechanisms of the marmot (Marmota flaviventris). Acute experiments are performed to determine the effectiveness of reflex responses to a pressor agent (phenylephine) and a depressor agent (nitroglycerine) when the baroreceptors and cardiopulmonary receptors are eliminated sequentially. Chronic experiments are performed with isolated carotid sinus preparations seasonally and during hibernation. The studies should indicate the seasonal alteration of blood pressure control and indicate the contribution of carotid sinus mechanisms to the control of blood pressure by the hibernating animal.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL030491-03
Application #
3341513
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1983-07-01
Project End
1986-12-31
Budget Start
1985-07-01
Budget End
1986-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Type
Schools of Medicine
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Zatzman, M L; Thornhill, G V (1989) Plasma levels of atrial natriuretic factor in nonhibernating and hibernating marmots. Cryobiology 26:196-8
Zatzman, M L; Thornhill, G V (1988) Effects of anesthetics on cardiovascular responses of the marmot Marmota flaviventris. Cryobiology 25:212-26
Zatzman, M L; Thornhill, G V (1987) Seasonal variation of cardiovascular function in the marmot, Marmota flaviventris. Cryobiology 24:376-85