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Schedin-Weiss, Sophia; Desai, Umesh R; Bock, Susan C et al. (2004) Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change. Biochemistry 43:675-83
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Jairajpuri, Mohamad Aman; Lu, Aiqin; Desai, Umesh et al. (2003) Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation. J Biol Chem 278:15941-50
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Schedin-Weiss, Sophia; Arocas, Veronique; Bock, Susan C et al. (2002) Specificity of the basic side chains of Lys114, Lys125, and Arg129 of antithrombin in heparin binding. Biochemistry 41:12369-76
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Olson, Steven T; Bjork, Ingemar; Bock, Susan C (2002) Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants. Trends Cardiovasc Med 12:198-205
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Schedin-Weiss, Sophia; Desai, Umesh R; Bock, Susan C et al. (2002) Importance of lysine 125 for heparin binding and activation of antithrombin. Biochemistry 41:4779-88
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Jairajpuri, Mohamad Aman; Lu, Aiqin; Bock, Susan C (2002) Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition. J Biol Chem 277:24460-5
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Chuang, Y J; Swanson, R; Raja, S M et al. (2001) The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation. Biochemistry 40:6670-9
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Arocas, V; Bock, S C; Raja, S et al. (2001) Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding. J Biol Chem 276:43809-17
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Arocas, V; Turk, B; Bock, S C et al. (2000) The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139. Biochemistry 39:8512-8
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Desai, U; Swanson, R; Bock, S C et al. (2000) Role of arginine 129 in heparin binding and activation of antithrombin. J Biol Chem 275:18976-84
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