Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL030712-13A1
Application #
2216701
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-10-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Schedin-Weiss, Sophia; Desai, Umesh R; Bock, Susan C et al. (2004) Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change. Biochemistry 43:675-83
Jairajpuri, Mohamad Aman; Lu, Aiqin; Desai, Umesh et al. (2003) Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation. J Biol Chem 278:15941-50
Schedin-Weiss, Sophia; Arocas, Veronique; Bock, Susan C et al. (2002) Specificity of the basic side chains of Lys114, Lys125, and Arg129 of antithrombin in heparin binding. Biochemistry 41:12369-76
Olson, Steven T; Bjork, Ingemar; Bock, Susan C (2002) Identification of critical molecular interactions mediating heparin activation of antithrombin: implications for the design of improved heparin anticoagulants. Trends Cardiovasc Med 12:198-205
Schedin-Weiss, Sophia; Desai, Umesh R; Bock, Susan C et al. (2002) Importance of lysine 125 for heparin binding and activation of antithrombin. Biochemistry 41:4779-88
Jairajpuri, Mohamad Aman; Lu, Aiqin; Bock, Susan C (2002) Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition. J Biol Chem 277:24460-5
Chuang, Y J; Swanson, R; Raja, S M et al. (2001) The antithrombin P1 residue is important for target proteinase specificity but not for heparin activation of the serpin. Characterization of P1 antithrombin variants with altered proteinase specificity but normal heparin activation. Biochemistry 40:6670-9
Arocas, V; Bock, S C; Raja, S et al. (2001) Lysine 114 of antithrombin is of crucial importance for the affinity and kinetics of heparin pentasaccharide binding. J Biol Chem 276:43809-17
Arocas, V; Turk, B; Bock, S C et al. (2000) The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139. Biochemistry 39:8512-8
Desai, U; Swanson, R; Bock, S C et al. (2000) Role of arginine 129 in heparin binding and activation of antithrombin. J Biol Chem 275:18976-84

Showing the most recent 10 out of 26 publications