Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031515-13
Application #
2028146
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1983-12-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Physiology
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Belmadani, Souad; Bernal, Juan; Wei, Chih-Chang et al. (2007) A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol 171:777-89
Zhou, Yong; Poczatek, Maria H; Berecek, Kathleen H et al. (2006) Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun 339:633-41
Berecek, Kathleen H; Reaves, Phyllis; Raizada, Mohan (2005) Effects of early perturbation of the renin-angiotensin system on cardiovascular remodeling in spontaneously hypertensive rats. Vascul Pharmacol 42:93-8
Fang, Z; Sripairojthikoon, W; Calhoun, D A et al. (1999) Interaction between lifetime captopril treatment and NaCI-sensitive hypertension in spontaneously hypertensive rats and Wistar-Kyoto rats. J Hypertens 17:983-91
Roysommuti, S; Mozaffari, M S; Berecek, K H et al. (1999) Lifetime treatment with captopril improves renal function in spontaneously hypertensive rats. Clin Exp Hypertens 21:1315-25
Keaton, A K; Clark, J T (1998) Effects of angiotensin II on sexual function, blood pressure, and fluid intake are differentially affected by AT-1 receptor blockade. Physiol Behav 64:339-46
Keaton, A K; White, C R; Berecek, K H (1998) Captopril treatment and its withdrawal prevents impairment of endothelium-dependent responses in the spontaneously hypertensive rat. Clin Exp Hypertens 20:847-66
Regan, C P; Anderson, P G; Bishop, S P et al. (1997) Pressure-independent effects of AT1-receptor antagonism on cardiovascular remodeling in aortic-banded rats. Am J Physiol 272:H2131-8
Zhang, L; Edwards, D G; Berecek, K H (1996) Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin Exp Hypertens 18:201-26
Berecek, K H; Zhang, L (1995) Biochemistry and cell biology of angiotensin-converting enzyme and converting enzyme inhibitors. Adv Exp Med Biol 377:141-68

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