Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL032994-12
Application #
2217145
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1984-08-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Starmer, C F (1997) The cardiac vulnerable period and reentrant arrhythmias: targets of anti- and proarrhythmic processes. Pacing Clin Electrophysiol 20:445-54
Liu, L; Krinsky, V I; Grant, A O et al. (1996) Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties. Am J Physiol 270:H386-97
Starobin, J M; Zilberter, Y I; Rusnak, E M et al. (1996) Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias. Biophys J 70:581-94
Spach, M S; Starmer, C F (1995) Altering the topology of gap junctions a major therapeutic target for atrial fibrillation. Cardiovasc Res 30:337-44
Starmer, C F; Romashko, D N; Reddy, R S et al. (1995) Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. Circulation 92:595-605
Zilberter YuI; Starmer, C F; Starobin, J et al. (1994) Late Na channels in cardiac cells: the physiological role of background Na channels. Biophys J 67:153-60
Zilberter, Y I; Starmer, C F; Grant, A O (1994) Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine. Am J Physiol 266:H2007-17
Starmer, C F; Reddy, M R; Namasivayam, A et al. (1994) Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. Indian J Physiol Pharmacol 38:259-66
Whalley, D W; Wendt, D J; Starmer, C F et al. (1994) Voltage-independent effects of extracellular K+ on the Na+ current and phase 0 of the action potential in isolated cardiac myocytes. Circ Res 75:491-502
Grant, A O; Wendt, D J; Zilberter, Y et al. (1993) Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. J Membr Biol 136:199-214

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