Abstract

The objective of this project is the study of basic biophysical processes which affect the electrical activity of the heart, and determine its reflection in epicardial and body surface potentials. This will be achieved through the development of theoretical (computer) model simulation.
Specific aims are: (1) The reconstruction of epicardial potentials from body surface potential distributions. This will permit a non-invasive, detailed examination of regional electrical events within the heart (site of origin of arrhythmids, location of pre-excitation in WPW syndrome, location and size of ischemic and infarcted regions, nature of conduction abnormalities). (2) The generation of activation isochrones, and the computation of epicardial potentials for a variety of (normal and abnormal) potentials. This will permit the study of volume conductor effects, and will enhance our understanding of the relationships between surface potentials, epicardial potentials, and cardiac events. The simulation studies will enhance the research and diagnostic capacity of both body surface and epicardial potentials. The models will be utilized in the interpretation of clinical body surface potential maps, obtained with a simultaneous 180 electrode mapping system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL033343-01A1
Application #
3345145
Study Section
(SSS)
Project Start
1985-07-01
Project End
1988-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Xu, Jiajing; Rudy, Yoram (2018) Effects of ?-subunit on gating of a potassium ion channel: Molecular simulations of cardiac IKs activation. J Mol Cell Cardiol 124:35-44
Robinson, Clifford G; Samson, Pamela P; Moore, Kaitlin M S et al. (2018) Phase I/II Trial of Electrophysiology-Guided Noninvasive Cardiac Radioablation for Ventricular Tachycardia. Circulation :
Ramasubramanian, Smiruthi; Rudy, Yoram (2018) The Structural Basis of IKs Ion-Channel Activation: Mechanistic Insights from Molecular Simulations. Biophys J 114:2584-2594
Andrews, Christopher M; Srinivasan, Neil T; Rosmini, Stefania et al. (2017) Response by Andrews et al to Letter Regarding Article, ""Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging"". Circ Arrhythm Electrophysiol 10:
Zhang, Junjie; Hocini, Mélèze; Strom, Maria et al. (2017) The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients. JACC Clin Electrophysiol 3:894-904
Andrews, Christopher M; Srinivasan, Neil T; Rosmini, Stefania et al. (2017) Electrical and Structural Substrate of Arrhythmogenic Right Ventricular Cardiomyopathy Determined Using Noninvasive Electrocardiographic Imaging and Late Gadolinium Magnetic Resonance Imaging. Circ Arrhythm Electrophysiol 10:
Rudy, Yoram (2017) Noninvasive ECG imaging (ECGI): Mapping the arrhythmic substrate of the human heart. Int J Cardiol 237:13-14
Cuculich, Phillip S; Schill, Matthew R; Kashani, Rojano et al. (2017) Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia. N Engl J Med 377:2325-2336
Lee, Hsiang-Chun; Rudy, Yoram; Liang, Hongwu et al. (2017) Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling. J Med Biol Eng 37:780-789
Nekouzadeh, Ali; Rudy, Yoram (2016) Conformational changes of an ion-channel during gating and emerging electrophysiologic properties: Application of a computational approach to cardiac Kv7.1. Prog Biophys Mol Biol 120:18-27

Showing the most recent 10 out of 89 publications