Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL033540-11
Application #
2217264
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1989-08-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Shasby, D Michael; Winter, Michael C (2011) H1 and PAR2 receptors enhance delivery of immune-competent cells and molecules by interrupting E-cadherin adhesion in epithelia. Trans Am Clin Climatol Assoc 122:217-28
Winter, Michael C; Shasby, Sandra; Shasby, D Michael (2008) Compromised E-cadherin adhesion and epithelial barrier function with activation of G protein-coupled receptors is rescued by Y-to-F mutations in beta-catenin. Am J Physiol Lung Cell Mol Physiol 294:L442-8
Winter, Michael C; Shasby, Sandra S; Ries, Dana R et al. (2006) PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists. Am J Physiol Lung Cell Mol Physiol 291:L628-35
Winter, Michael C; Shasby, Sandra S; Ries, Dana R et al. (2004) Histamine selectively interrupts VE-cadherin adhesion independently of capacitive calcium entry. Am J Physiol Lung Cell Mol Physiol 287:L816-23
Zabner, Joseph; Winter, Michael; Excoffon, Katherine J D Ashbourne et al. (2003) Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability. J Appl Physiol 95:394-401
Moy, A B; Winter, M; Kamath, A et al. (2000) Histamine alters endothelial barrier function at cell-cell and cell-matrix sites. Am J Physiol Lung Cell Mol Physiol 278:L888-98
Winter, M C; Kamath, A M; Ries, D R et al. (1999) Histamine alters cadherin-mediated sites of endothelial adhesion. Am J Physiol 277:L988-95
Moy, A B; Bodmer, J E; Blackwell, K et al. (1998) cAMP protects endothelial barrier function independent of inhibiting MLC20-dependent tension development. Am J Physiol 274:L1024-9
Shasby, D M; Stevens, T; Ries, D et al. (1997) Thrombin inhibits myosin light chain dephosphorylation in endothelial cells. Am J Physiol 272:L311-9
Bodmer, J E; Van Engelenhoven, J; Reyes, G et al. (1997) Isometric tension of cultured endothelial cells: new technical aspects. Microvasc Res 53:261-71

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