Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL034228-06
Application #
3346985
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1989-07-08
Project End
1992-08-31
Budget Start
1989-07-08
Budget End
1989-08-31
Support Year
6
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Murlas, C G; Sharma, A C; Gulati, A et al. (1997) Interleukin-1 beta increases airway epithelial cell mitogenesis partly by stimulating endothelin-1 production. Lung 175:117-26
Murlas, C G; Gulati, A; Singh, G et al. (1995) Endothelin-1 stimulates proliferation of normal airway epithelial cells. Biochem Biophys Res Commun 212:953-9
Murlas, C G; Lang, Z; Chodimella, V (1993) Dexamethasone reduces tachykinin but not ACh airway hyperreactivity after O3. Lung 171:109-21
Lang, Z; Murlas, C G (1993) Dexamethasone increases airway epithelial cell neutral endopeptidase by enhancing transcription and new protein synthesis. Lung 171:161-72
Murlas, C G; Lang, Z; Williams, G J et al. (1992) Aerosolized neutral endopeptidase reverses ozone-induced airway hyperreactivity to substance P. J Appl Physiol 72:1133-41
Lang, Z; Murlas, C G (1992) Neutral endopeptidase of a human airway epithelial cell line recovers after hypochlorous acid exposure: dexamethasone accelerates this by stimulating neutral endopeptidase mRNA synthesis. Am J Respir Cell Mol Biol 7:300-6
Chodimella, V; Skidgel, R A; Krowiak, E J et al. (1991) Lung peptidases, including carboxypeptidase, modulate airway reactivity to intravenous bradykinin. Am Rev Respir Dis 144:869-74
Lang, Z H; Murlas, C G (1991) HOCl exposure of a human airway epithelial cell line decreases its plasma membrane neutral endopeptidase. Lung 169:311-23
Murlas, C G; Murphy, T P; Lang, Z (1990) HOCl causes airway substance P hyperresponsiveness and neutral endopeptidase hypoactivity. Am J Physiol 258:L361-8
Murlas, C G; Murphy, T P; Chodimella, V (1990) O3-induced mucosa-linked airway muscle hyperresponsiveness in the guinea pig. J Appl Physiol 69:7-13

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