Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL035559-10
Application #
2217852
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1985-12-01
Project End
1999-02-28
Budget Start
1996-03-08
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Biochemistry
Type
Schools of Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Levasseur, Dana N; Ryan, Thomas M; Reilly, Michael P et al. (2004) A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. J Biol Chem 279:27518-24
Zhou, Dewang; Ren, Jin-Xiang; Ryan, Thomas M et al. (2004) Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. Nucleic Acids Res 32:e128
Masuoka, Howard C; Townes, Tim M (2002) Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 99:736-45
Chen, W Y; Bailey, E C; McCune, S L et al. (1997) Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci U S A 94:5798-803
Farmer, S C; Sun, C W; Winnier, G E et al. (1997) The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev 11:786-98
Pawlik, K M; Townes, T M (1995) Autonomous, erythroid-specific DNase I hypersensitive site formed by human beta-globin locus control region (LCR) 5' HS 2 in transgenic mice. Dev Biol 169:728-32
Pawlik, K M; Sun, C W; Higgins, N P et al. (1995) End joining of genomic DNA and transgene DNA in fertilized mouse eggs. Gene 165:173-81
Ciavatta, D J; Ryan, T M; Farmer, S C et al. (1995) Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells. Proc Natl Acad Sci U S A 92:9259-63
Donze, D; Townes, T M; Bieker, J J (1995) Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching. J Biol Chem 270:1955-9
McCune, S L; Reilly, M P; Chomo, M J et al. (1994) Recombinant human hemoglobins designed for gene therapy of sickle cell disease. Proc Natl Acad Sci U S A 91:9852-6

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