Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036153-06
Application #
2218086
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1986-09-30
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Physiology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Lehman, William; Li, Xiaochuan; Kiani, Farooq A et al. (2018) Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophys J 115:1082-1092
Farman, Gerrie P; Rynkiewicz, Michael J; Orzechowski, Marek et al. (2018) HCM and DCM cardiomyopathy-linked ?-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys 647:84-92
Rynkiewicz, Michael J; Fischer, Stefan; Lehman, William (2016) The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys 609:51-58
Alamo, Lorenzo; Li, Xiaochuan Edward; Espinoza-Fonseca, L Michel et al. (2015) Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back. Mol Biosyst 11:2180-9
Begonja, Antonija Jurak; Pluthero, Fred G; Suphamungmee, Worawit et al. (2015) FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood 126:80-8
Lehman, William; Li, Xiaochuan Edward; Orzechowski, Marek et al. (2014) The structural dynamics of ?-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules. Arch Biochem Biophys 552-553:68-73
Li, Xiaochuan Edward; Suphamungmee, Worawit; Janco, Miro et al. (2012) The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy. Biochem Biophys Res Commun 424:493-6
Suphamungmee, Worawit; Nakamura, Fumihiko; Hartwig, John H et al. (2012) Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin. J Mol Biol 424:248-56
East, Daniel A; Sousa, Duncan; Martin, Stephen R et al. (2011) Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin. Biochem J 438:265-73
Moore, Jeffrey R; Li, Xiaochuan; Nirody, Jasmine et al. (2011) Structural implications of conserved aspartate residues located in tropomyosin's coiled-coil core. Bioarchitecture 1:250-255

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