Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036235-11
Application #
2218100
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1988-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Vasilakaki, Sofia; Barbayianni, Efrosini; Leonis, Georgios et al. (2016) Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorg Med Chem 24:1683-95
Vijay, Rahul; Hua, Xiaoyang; Meyerholz, David K et al. (2015) Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection. J Exp Med 212:1851-68
Yamamoto, Kei; Miki, Yoshimi; Sato, Mariko et al. (2015) The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med 212:1901-19
Rousseau, Matthieu; Belleannee, Clemence; Duchez, Anne-Claire et al. (2015) Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. PLoS One 10:e0116812
Boudreau, Luc H; Duchez, Anne-Claire; Cloutier, Nathalie et al. (2014) Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood 124:2173-83
Sato, Hiroyasu; Taketomi, Yoshitaka; Ushida, Ayako et al. (2014) The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metab 20:119-32
Taketomi, Yoshitaka; Ueno, Noriko; Kojima, Takumi et al. (2013) Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol 14:554-63
Bollinger, James G; Naika, Gajendra S; Rohan, Gajendra et al. (2013) LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity. J Lipid Res 54:3523-30
Oslund, Rob C; Gelb, Michael H (2012) Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A(2) and hyaluronic acid-linked inhibitor conjugates. Biochemistry 51:8617-26
Hallstrand, T S; Lai, Y; Ni, Z et al. (2011) Relationship between levels of secreted phospholipase A? groups IIA and X in the airways and asthma severity. Clin Exp Allergy 41:801-10

Showing the most recent 10 out of 23 publications