Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036271-10
Application #
2218114
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1987-07-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Arystarkhova, Elena; Sweadner, Kathleen J (2016) Functional Studies of Na(+),K(+)-ATPase Using Transfected Cell Cultures. Methods Mol Biol 1377:321-32
Sweadner, Kathleen J (2016) Colorimetric Assays of Na,K-ATPase. Methods Mol Biol 1377:89-104
Arystarkhova, Elena; Liu, Yi B; Salazar, Cynthia et al. (2013) Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase. J Biol Chem 288:7077-85
Sweadner, Kathleen J; Pascoa, Jennifer L; Salazar, Cynthia A et al. (2011) Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA. J Biol Chem 286:18290-300
Arystarkhova, Elena; Donnet, Claudia; Munoz-Matta, Ana et al. (2007) Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress. Am J Physiol Cell Physiol 292:C1179-91
Jia, Li-Guo; Donnet, Claudia; Bogaev, Roberta C et al. (2005) Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am J Physiol Heart Circ Physiol 288:H1982-8
Arystarkhova, Elena; Sweadner, Kathleen J (2005) Splice variants of the gamma subunit (FXYD2) and their significance in regulation of the Na, K-ATPase in kidney. J Bioenerg Biomembr 37:381-6
Jones, D Holstead; Li, Tony Y; Arystarkhova, Elena et al. (2005) Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability. J Biol Chem 280:19003-11
Sweadner, Kathleen J (2005) Phospholemman: a new force in cardiac contractility. Circ Res 97:510-1
Wetzel, Randall K; Pascoa, Jennifer L; Arystarkhova, Elena (2004) Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth. J Biol Chem 279:41750-7

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