Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036365-10
Application #
2218133
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1985-07-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Kumar, Yogesh; Vadivel, Kanagasabai; Schmidt, Amy E et al. (2014) Decoy plasminogen receptor containing a selective Kunitz-inhibitory domain. Biochemistry 53:505-17
Vadivel, Kanagasabai; Ponnuraj, Sathya-Moorthy; Kumar, Yogesh et al. (2014) Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem 289:31647-61
Vadivel, Kanagasabai; Agah, Sayeh; Messer, Amanda S et al. (2013) Structural and functional studies of ?-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physiological calcium. J Mol Biol 425:1961-1981
Geng, Y; Verhamme, I M; Sun, M F et al. (2013) Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa. J Thromb Haemost 11:1374-84
Geng, Yipeng; Verhamme, Ingrid M; Messer, Amanda et al. (2012) A sequential mechanism for exosite-mediated factor IX activation by factor XIa. J Biol Chem 287:38200-9
Bajaj, Madhu S; Ogueli, Godwin I; Kumar, Yogesh et al. (2011) Engineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variant. J Biol Chem 286:4329-40
Messer, A S; Velander, W H; Bajaj, S P (2009) Contribution of magnesium in binding of factor IXa to the phospholipid surface: implications for vitamin K-dependent coagulation proteins. J Thromb Haemost 7:2151-3
Agah, S; Bajaj, S P (2009) Role of magnesium in factor XIa catalyzed activation of factor IX: calcium binding to factor IX under physiologic magnesium. J Thromb Haemost 7:1426-8
Schmidt, Amy E; Sun, Mao-fu; Ogawa, Taketoshi et al. (2008) Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa. Biochemistry 47:1326-35
Bajaj, M S; Kuppuswamy, M N; Manepalli, A N et al. (1999) Transcriptional expression of tissue factor pathway inhibitor, thrombomodulin and von Willebrand factor in normal human tissues. Thromb Haemost 82:1047-52

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