Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL036418-09S1
Application #
873359
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1985-08-01
Project End
1997-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
9
Fiscal Year
1994
Total Cost
Indirect Cost
Name
George Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052
Mak, I Tong; Zhang, Jingyun; Weglicki, William B (2002) Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide. Pharmacol Res 45:27-33
Dickens, Benjamin F; Weglicki, William B; Boehme, Patricia A et al. (2002) Antioxidant and lysosomotropic properties of acridine-propranolol: protection against oxidative endothelial cell injury. J Mol Cell Cardiol 34:129-37
Komarov, A M; Mak, I T; Weglicki, W B (2000) The origin of dinitrosyl-iron complex in endothelial cells. Ann N Y Acad Sci 899:407-10
Mak, I T; Komarov, A M; Kramer, J H et al. (2000) Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity. Cell Mol Biol (Noisy-le-grand) 46:1337-44
Mak, I T; Zhang, J; Weglicki, W B (2000) Cytoprotective properties of nisoldipine and amlodipine against oxidative endothelial cell injury. Ann N Y Acad Sci 899:403-6
Kramer, J H; Lightfoot, F G; Weglicki, W B (2000) Cardiac tissue iron: effects on post-ischemic function and free radical production, and its possible role during preconditioning. Cell Mol Biol (Noisy-le-grand) 46:1313-27
Loyevsky, M; Sacci Jr, J B; Boehme, P et al. (1999) Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Exp Parasitol 91:105-14
Loyevsky, M; John, C; Dickens, B et al. (1999) Chelation of iron within the erythrocytic Plasmodium falciparum parasite by iron chelators. Mol Biochem Parasitol 101:43-59
Komarov, A M; Mattson, D L; Mak, I T et al. (1998) Iron attenuates nitric oxide level and iNOS expression in endotoxin-treated mice. FEBS Lett 424:253-6
Mak, I T; Dickens, B F; Komarov, A M et al. (1997) Activation of the neutrophil and loss of plasma glutathione during Mg-deficiency--modulation by nitric oxide synthase inhibition. Mol Cell Biochem 176:35-9

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