Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL037063-15
Application #
6536891
Study Section
Physiological Chemistry Study Section (PC)
Program Officer
Applebaum-Bowden, Deborah
Project Start
1991-07-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
15
Fiscal Year
2002
Total Cost
$400,500
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Huang, Yadong (2006) Apolipoprotein E and Alzheimer disease. Neurology 66:S79-85
Mahley, R W; Huang, Y (2006) Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl 185:8-14
Xu, Qin; Bernardo, Aubrey; Walker, David et al. (2006) Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J Neurosci 26:4985-94
Ramaswamy, Gayathri; Xu, Qin; Huang, Yadong et al. (2005) Effect of domain interaction on apolipoprotein E levels in mouse brain. J Neurosci 25:10658-63
Ye, Shiming; Huang, Yadong; Mullendorff, Karin et al. (2005) Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A 102:18700-5
Chang, Shengjun; ran Ma, Tian; Miranda, R Dennis et al. (2005) Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc Natl Acad Sci U S A 102:18694-9
Harris, Faith M; Brecht, Walter J; Xu, Qin et al. (2004) Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 279:44795-801
Harris, Faith M; Tesseur, Ina; Brecht, Walter J et al. (2004) Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease. J Biol Chem 279:3862-8
Huang, Yadong; Weisgraber, Karl H; Mucke, Lennart et al. (2004) Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci 23:189-204
Grehan, S; Allan, C; Tse, E et al. (2001) Expression of the apolipoprotein E gene in the skin is controlled by a unique downstream enhancer. J Invest Dermatol 116:77-84

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