Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL038199-11S1
Application #
2879383
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-04-01
Project End
2002-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Monaghan, M; Wakabayashi, H; Griffiths, A E et al. (2016) Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway. J Thromb Haemost 14:1021-30
Leong, Lilley; Sim, Derek; Patel, Chandra et al. (2015) Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models. Blood 125:392-8
Monaghan, M; Wakabayashi, H; Griffiths, A et al. (2014) Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit. Thromb Haemost 112:495-502
Kosloski, Matthew P; Shetty, Krithika A; Wakabayashi, Hironao et al. (2014) Effects of replacement of factor VIII amino acids Asp519 and Glu665 with Val on plasma survival and efficacy in vivo. AAPS J 16:1038-45
Wakabayashi, Hironao; Monaghan, Morgan; Fay, Philip J (2014) Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII. J Biol Chem 289:14020-9
Wakabayashi, H; Wintermute, J M; Fay, P J (2014) Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa. Thromb Haemost 112:43-52
Griffiths, Amy E; Wintermute, Jennifer; Newell-Caito, Jennifer L et al. (2013) Residues flanking scissile bonds in Factor VIII modulate rates of cleavage and proteolytic activation catalyzed by Factor Xa. Biochemistry 52:8060-8
Wakabayashi, Hironao; Fay, Philip J (2013) Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa. J Biol Chem 288:31289-97
Wakabayashi, Hironao; Fay, Philip J (2013) Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer. Biochem J 452:293-301
Takeyama, Masahiro; Wakabayashi, Hironao; Fay, Philip J (2013) Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site. Thromb Haemost 109:187-98

Showing the most recent 10 out of 93 publications