Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL038644-12S1
Application #
2758750
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-08-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Genetics
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Kurachi, Sumiko; Huo, Jeffrey S; Ameri, Afshin et al. (2009) An age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. Proc Natl Acad Sci U S A 106:7921-6
Zhang, Kezhong; Kurachi, Sumiko; Kurachi, Kotoku (2003) Limitation in use of heterologous reporter genes for gene promoter analysis. Silencer activity associated with the cloramphenicol acetyltransferase reporter gene. J Biol Chem 278:4826-30
Ameri, Afshin; Kurachi, Sumiko; Sueishi, Katsuo et al. (2003) Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX. Blood 101:1871-3
Zhang, Kezhong; Kurachi, Sumiko; Kurachi, Kotoku (2002) New function for age-related stability element in conferring strict tissue-specific expression of human factor IX and protein C genes. Thromb Haemost 88:537-8
Zhang, Kezhong; Kurachi, Sumiko; Kurachi, Kotoku (2002) Genetic mechanisms of age regulation of protein C and blood coagulation. J Biol Chem 277:4532-40
Holoshitz, N; Kurachi, K; Kurachi, S (2000) Carrier analysis of a moderately affected haemophilia B family. Haemophilia 6:713-4
Kurachi, K; Kurachi, S (2000) Genetic mechanisms of age regulation of blood coagulation: factor IX model. Arterioscler Thromb Vasc Biol 20:902-6
Kurachi, K; Zhang, K; Ameri, A et al. (2000) Genetic and molecular mechanisms of age regulation (homeostasis) of blood coagulation. IUBMB Life 49:189-96
Kawamura, S; Kurachi, S; Deyashiki, Y et al. (1999) Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene. Eur J Biochem 262:755-64
Hsu, W; Kawamura, S; Fontaine, J M et al. (1999) Organization and significance of LINE-1-derived sequences in the 5' flanking region of the factor IX gene. Thromb Haemost 82:1782-3

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