The capabilities of Magnetic Resonance (MR) imaging of the central car- diovascular system (i.e., heart, great arteries and veins, small vessel networks in the thorax) have been advanced in recent years from primarily a definition of the anatomy of the walls of the cardiac chambers and the large vessels to the evaluation of physiologic and hemodynamic parameters using dynamic imaging and blood-signal-enhancing (""""""""bright blood"""""""") sequences. Evaluation of the central cardiovascular system in normal and diseased states using MR imaging, however, remains limited due to nonuniformity of the blood signal in the various intracardiac/intravascular blood pools on dynamic display, difficulties with displaying the complex branching patterns of the large vasculature systems in the thorax, and present inability to provide the resolution, complex display, and motion compensation required for imaging small vessel networks, such as the coronary artery system. Our primary goal in this proposed research is to overcome these limitations by means of technical development and application. Technical development which is planned involves work in the following areas: (1) reduction of phase errors; (2) reduction of in-flow artifact; (3) reduction of periodic motion artifact; and (4) improvement of image resolution and contrast. High resolution, high signal-to-noise MR imaging in the presence of physiologic cardiac and respiratory motion is sought. The application of these techniques is concerned with the following: (5) dynamic display of intracardiac blood pools; (6) static display of the major thoracic arterial systems; and (7) display of small vessel networks in the thorax, especially the coronary arteries and their branches. This clinical aspect of the project will be concerned primarily with the assessment of the capability of our techniques to produce images resembling the corresponding angiographic """"""""gold standards"""""""". This aspect will be pursued primarily using volunteer controls and patients. The outcome of this effort would be the improved detection with imaging of the presence or absence of a large range of central cardiovascular diseases, and the improved description of the anatomic and functional aspects of the disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL038698-05
Application #
3355036
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1993-08-01
Project End
1995-08-31
Budget Start
1993-09-30
Budget End
1994-08-31
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Pang, Jianing; Chen, Yuhua; Fan, Zhaoyang et al. (2016) High efficiency coronary MR angiography with nonrigid cardiac motion correction. Magn Reson Med 76:1345-1353
Pang, Jianing; Sharif, Behzad; Arsanjani, Reza et al. (2015) Accelerated whole-heart coronary MRA using motion-corrected sensitivity encoding with three-dimensional projection reconstruction. Magn Reson Med 73:284-91
Pang, Jianing; Sharif, Behzad; Fan, Zhaoyang et al. (2014) ECG and navigator-free four-dimensional whole-heart coronary MRA for simultaneous visualization of cardiac anatomy and function. Magn Reson Med 72:1208-17
Nguyen, Christopher; Fan, Zhaoyang; Sharif, Behzad et al. (2014) In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: a motion compensated diffusion-prepared balanced steady-state free precession approach. Magn Reson Med 72:1257-67
Sharif, Behzad; Dharmakumar, Rohan; Arsanjani, Reza et al. (2014) Non-ECG-gated myocardial perfusion MRI using continuous magnetization-driven radial sampling. Magn Reson Med 72:1620-8
Pang, Jianing; Bhat, Himanshu; Sharif, Behzad et al. (2014) Whole-heart coronary MRA with 100% respiratory gating efficiency: self-navigated three-dimensional retrospective image-based motion correction (TRIM). Magn Reson Med 71:67-74
Sharif, Behzad; Dharmakumar, Rohan; LaBounty, Troy et al. (2014) Towards elimination of the dark-rim artifact in first-pass myocardial perfusion MRI: removing Gibbs ringing effects using optimized radial imaging. Magn Reson Med 72:124-36
Nguyen, Christopher; Fan, Zhaoyang; Xie, Yibin et al. (2014) In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 16:68
He, Yi; Zhang, Zhaoqi; Dai, Qinyi et al. (2012) Accuracy of MRI to identify the coronary artery plaque: a comparative study with intravascular ultrasound. J Magn Reson Imaging 35:72-8
Yang, Qi; Li, Kuncheng; Liu, Xin et al. (2012) 3.0T whole-heart coronary magnetic resonance angiography performed with 32-channel cardiac coils: a single-center experience. Circ Cardiovasc Imaging 5:573-9

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