The purpose of the project is to develop magnetic resonance imaging (MRI) techniques to improve coronary artery angiography (MRA). MRA is a promising screening test to select candidates for conventional angiography. Substantial progress has been made in coronary MRA in the last decade. However, preliminary clinical studies reveal that current coronary MRA techniques suffer from substantial technical failures and false positives. The objectives of the proposed project are to develop novel coronary MRA techniques to achieve the following goals: (a) improving the spatial resolution by a factor of 4-5 from current protocols, images will have true isotropic resolution in all three directions with whole-heart coverage in one scan;(b) increasing imaging speed so that whole-heart, isotropic resolution MRA can be acquired in a practical imaging time;(c) improving motion compensation schemes to allow more consistent and complete elimination of image artifacts caused by cardiac and respiratory motion.
The specific aims of the project are:
Aim 1 : To test the hypothesis that parallel acquisition projection reconstruction allows whole-heart, 0.7-mm isotropic resolution coronary MRA in 10-15 min Aim 2: To test the hypothesis that self-gating can be used for synchronization of image acquisition to the respiratory cycle in cardiac motion-resolved whole-heart coronary MRA with more accurate motion correction than diaphragmatic navigators Aim 3: To test the hypothesis that self-gating can be used for synchronization of image acquisition to the cardiac cycle in cardiac motio-resolved whole-heart coronary MRA with improved arrhythmia rejection capabilities over ECG-gating Aim 4: To verify that self-gated, cardiac motion-resolved whole-heart coronary MRA can accurately depict coronary artery stenoses in patients The end point of the project is the development and clinical validation of a new imaging method capable of acquiring whole-heart coronary MRA with substantially improved and isotropic spatial resolution and markedly reduced residual motion artifacts. It is expected that such a technique will substantially increase diagnostic accuracy of coronary disease, and facilitate the widespread clinical application of coronary MRA.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Evans, Frank
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Cedars-Sinai Medical Center
Los Angeles
United States
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Pang, Jianing; Chen, Yuhua; Fan, Zhaoyang et al. (2016) High efficiency coronary MR angiography with nonrigid cardiac motion correction. Magn Reson Med 76:1345-1353
Pang, Jianing; Sharif, Behzad; Arsanjani, Reza et al. (2015) Accelerated whole-heart coronary MRA using motion-corrected sensitivity encoding with three-dimensional projection reconstruction. Magn Reson Med 73:284-91
Sharif, Behzad; Dharmakumar, Rohan; Arsanjani, Reza et al. (2014) Non-ECG-gated myocardial perfusion MRI using continuous magnetization-driven radial sampling. Magn Reson Med 72:1620-8
Pang, Jianing; Bhat, Himanshu; Sharif, Behzad et al. (2014) Whole-heart coronary MRA with 100% respiratory gating efficiency: self-navigated three-dimensional retrospective image-based motion correction (TRIM). Magn Reson Med 71:67-74
Sharif, Behzad; Dharmakumar, Rohan; LaBounty, Troy et al. (2014) Towards elimination of the dark-rim artifact in first-pass myocardial perfusion MRI: removing Gibbs ringing effects using optimized radial imaging. Magn Reson Med 72:124-36
Nguyen, Christopher; Fan, Zhaoyang; Xie, Yibin et al. (2014) In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson 16:68
Pang, Jianing; Sharif, Behzad; Fan, Zhaoyang et al. (2014) ECG and navigator-free four-dimensional whole-heart coronary MRA for simultaneous visualization of cardiac anatomy and function. Magn Reson Med 72:1208-17
Nguyen, Christopher; Fan, Zhaoyang; Sharif, Behzad et al. (2014) In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: a motion compensated diffusion-prepared balanced steady-state free precession approach. Magn Reson Med 72:1257-67
He, Yi; Zhang, Zhaoqi; Dai, Qinyi et al. (2012) Accuracy of MRI to identify the coronary artery plaque: a comparative study with intravascular ultrasound. J Magn Reson Imaging 35:72-8
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