Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL038834-10
Application #
2219063
Study Section
Physiology Study Section (PHY)
Project Start
1987-08-01
Project End
1997-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Iowa
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Li, Xiaochuan Edward; Tobacman, Larry S; Mun, Ji Young et al. (2011) Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophys J 100:1005-13
Sousa, Duncan; Cammarato, Anthony; Jang, Ken et al. (2010) Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys J 99:862-8
Kowlessur, Devanand; Tobacman, Larry S (2010) Troponin regulatory function and dynamics revealed by H/D exchange-mass spectrometry. J Biol Chem 285:2686-94
Kozaili, Julie Mouannes; Leek, Daniel; Tobacman, Larry S (2010) Dual regulatory functions of the thin filament revealed by replacement of the troponin I inhibitory peptide with a linker. J Biol Chem 285:38034-41
Ali, Laith F; Cohen, Joshua M; Tobacman, Larry S (2010) Push and pull of tropomyosin's opposite effects on myosin attachment to actin. A chimeric tropomyosin host-guest study. Biochemistry 49:10873-80
Kowlessur, Devanand; Tobacman, Larry S (2010) Low temperature dynamic mapping reveals unexpected order and disorder in troponin. J Biol Chem 285:38978-86
Siththanandan, V B; Tobacman, L S; Van Gorder, N et al. (2009) Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils. Pflugers Arch 458:761-76
Lehman, William; Gali?ska-Rakoczy, Agnieszka; Hatch, Victoria et al. (2009) Structural basis for the activation of muscle contraction by troponin and tropomyosin. J Mol Biol 388:673-81