Heparin on Hypoxic Pulmonary Hypertension and Remodeling

Hales, Charles A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL039150-08
• Application #: 2219200
• Study Section: Respiratory and Applied Physiology Study Section (RAP)
• Project Start: 1987-07-01
• Project End: 1997-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 8
• Fiscal Year: 1996

Institution

• Name: Massachusetts General Hospital
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02199

Publications

Zhao, Gaofeng; Seng, Jingjing; Beagle, John et al. (2015) Heparin reduces overcirculation-induced pulmonary artery remodeling through p38 MAPK in piglet. Ann Thorac Surg 99:1677-84

Yu, Lunyin; Hales, Charles A (2011) Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Respir Res 12:21

Yu, Lunyin; Hales, Charles A (2011) Silencing of sodium-hydrogen exchanger 1 attenuates the proliferation, hypertrophy, and migration of pulmonary artery smooth muscle cells via E2F1. Am J Respir Cell Mol Biol 45:923-30

Yu, Lunyin; Hales, Charles A (2011) Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice. BMC Cancer 11:331

Yu, Lunyin; Hales, Charles A (2011) Hypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells. J Vasc Res 48:465-75

Ochoa, Christiaan D; Garg, Hari G; Hales, Charles A et al. (2011) Low molecular weight hyaluronan, via AP-1 and NF-ýýB signalling, induces IL-8 in transformed bronchial epithelial cells. Swiss Med Wkly 141:w13255

Garg, Hari G; Mrabat, Hicham; Yu, Lunyin et al. (2011) Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells. Glycoconj J 28:419-26

Leu, Shaw-Wei; Shi, Liyun; Xu, Changqing et al. (2011) TLR4 through IFN-? promotes low molecular mass hyaluronan-induced neutrophil apoptosis. J Immunol 186:556-62

Zhao, Gaofeng; Shaik, Rahamthulla S; Zhao, Hang et al. (2011) Low molecular weight (LMW) heparin inhibits injury-induced femoral artery remodeling in mouse via upregulating CD44 expression. J Vasc Surg 53:1359-1367.e3

Yu, Lunyin; Quinn, Deborah A; Garg, Hari G et al. (2011) Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27. Am J Respir Cell Mol Biol 44:524-30