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Yang, Likui; Ding, Qiulan; Huang, Xin et al. (2012) Characterization of the heparin-binding site of the protein z-dependent protease inhibitor. Biochemistry 51:4078-85
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Duhan, Urmila (2011) Replacement of Phe274 with conserved residue Tyr274 for reactive center loop expulsion in antithrombin. Clin Appl Thromb Hemost 17:273-8
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Huang, Xin; Rezaie, Alireza R; Broze Jr, George J et al. (2011) Heparin is a major activator of the anticoagulant serpin, protein Z-dependent protease inhibitor. J Biol Chem 286:8740-51
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Olson, Steven T; Richard, Benjamin; Izaguirre, Gonzalo et al. (2010) Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors. Biochimie 92:1587-96
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Schedin-Weiss, Sophia; Richard, Benjamin; Olson, Steven T (2010) Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes. Arch Biochem Biophys 504:169-76
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Richard, Benjamin; Swanson, Richard; Olson, Steven T (2009) The signature 3-O-sulfo group of the anticoagulant heparin sequence is critical for heparin binding to antithrombin but is not required for allosteric activation. J Biol Chem 284:27054-64
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Gettins, Peter G W; Olson, Steven T (2009) Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement. FEBS Lett 583:3397-400
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Gettins, Peter G W; Olson, Steven T (2009) Exosite determinants of serpin specificity. J Biol Chem 284:20441-5
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Schedin-Weiss, Sophia; Richard, Benjamin; Hjelm, Rebecka et al. (2008) Antiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence. Biochemistry 47:13610-9
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Izaguirre, Gonzalo; Olson, Steven T (2006) Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa. J Biol Chem 281:13424-32
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Showing the most recent 10 out of 15 publications
