Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL039926-05
Application #
3356919
Study Section
Pathology A Study Section (PTHA)
Project Start
1988-02-01
Project End
1992-08-31
Budget Start
1991-12-23
Budget End
1992-08-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Polverini, Peter J; Nor, Jacques E; Peters, Martin C et al. (2003) Growth of human blood vessels in severe combined immunodeficient mice. A new in vivo model system of angiogenesis. Methods Mol Med 78:161-77
Lane, Brian R; Liu, Jianguo; Bock, Paul J et al. (2002) Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. J Virol 76:11570-83
Nor, J E; Peters, M C; Christensen, J B et al. (2001) Engineering and characterization of functional human microvessels in immunodeficient mice. Lab Invest 81:453-63
Nor, J E; Mitra, R S; Sutorik, M M et al. (2000) Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway. J Vasc Res 37:209-18
Polverini, P J; Nor, J E (1999) Apoptosis and predisposition to oral cancer. Crit Rev Oral Biol Med 10:139-52
Nor, J E; Christensen, J; Mooney, D J et al. (1999) Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 154:375-84
Nissen, N N; Polverini, P J; Koch, A E et al. (1998) Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 152:1445-52
Polverini, P J (1997) Role of the macrophage in angiogenesis-dependent diseases. EXS 79:11-28
Castle, V P; Dixit, V M; Polverini, P J (1997) Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells. Lab Invest 77:51-61
Hsu, S C; Volpert, O V; Steck, P A et al. (1996) Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1. Cancer Res 56:5684-91

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